DegronMD - Q14525(KRT33B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A248T	TCGA-CQ-6223	HNSC	TCGA	VVSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.0556
p.A248T	DO15318	HNSC	ICGC	VVSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.0556
p.A248T	SIDM00118	Colorectal Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.0556
p.A248T	ACH-001081	Colon/Colorectal Cancer	CCLE	VVSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.0556
p.A248T	HCC2998	large intestine	COSMIC	VVSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.0556
p.E252K	TCGA-FR-A729	SKCM	TCGA	VVSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1667
p.E252K	DO48618	SKCM	ICGC	VVSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1667
p.T249M	DO233715	GACA	ICGC	VVSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.0833
p.S262L	DO218863	SKCA	ICGC	VVSSS	DEG_SPOP_SBC_1	258:262	Mutation altering degron motif	0.7667
p.I272V	DO229264	THCA	ICGC	VVSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.0556
p.A270V	DO229216	THCA	ICGC	VVSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1111
p.A270V	DO229227	THCA	ICGC	VVSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1111
p.A270V	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1111
p.A270V	SIDM01147	Gastric Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1111
p.A270V	SIDM01650	Non-Cancerous	GDSC	VVSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1111
p.Q266E	DO229248	THCA	ICGC	VVSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.2222
p.Q264H	DO229250	THCA	ICGC	VVSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.2778
p.S261C	SIDM01662	Plasma Cell Myeloma	GDSC	VVSSS	DEG_SPOP_SBC_1	258:262	Mutation altering degron motif	0.7541
p.Y268C	ACH-000300	Kidney Cancer	CCLE	VVSSS	DEG_SPOP_SBC_1	258:262	Mutation blocking phosphorylation signal	0.6111

Kaplan plot for KRT33B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KRT33B

UniProt ID: Q14525

Entrez ID: 3884

Protein name: Keratin, type I cuticular Ha3-II (Hair keratin, type I Ha3-II) (Keratin-33B) (K33B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KRT33B in