DegronMD

Uniprot ID: Q14525

Source protein: Keratin, type I cuticular Ha3-II

Source gene: KRT33B

Class: DEG_SPOP_SBC_1

Location: 258:262

E3 ligase: SPOP

DEGRON score: 0.5895

ASA_SCORE: 79.28

COIL: 0.3968

CONS_SCORE: 0.6864

DSS_SCORE: 0.3322

HELIX: 0.5982

FCONS_SCORE: 1.1692

RIG_SCORE: 0.773

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A248T	TCGA-CQ-6223	HNSC	TCGA	VVSSS	DEG_SPOP_SBC_1	0.0556
p.A248T	DO15318	HNSC	ICGC	VVSSS	DEG_SPOP_SBC_1	0.0556
p.A248T	SIDM00118	Colorectal Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	0.0556
p.A248T	ACH-001081	Colon/Colorectal Cancer	CCLE	VVSSS	DEG_SPOP_SBC_1	0.0556
p.A248T	HCC2998	large_intestine	COSMIC	VVSSS	DEG_SPOP_SBC_1	0.0556
p.E252K	TCGA-FR-A729	SKCM	TCGA	VVSSS	DEG_SPOP_SBC_1	0.1667
p.E252K	DO48618	SKCM	ICGC	VVSSS	DEG_SPOP_SBC_1	0.1667
p.T249M	DO233715	GACA	ICGC	VVSSS	DEG_SPOP_SBC_1	0.0833
p.S262L	DO218863	SKCA	ICGC	VVSSS	DEG_SPOP_SBC_1	0.7667
p.I272V	DO229264	THCA	ICGC	VVSSS	DEG_SPOP_SBC_1	0.0556
p.A270V	DO229216	THCA	ICGC	VVSSS	DEG_SPOP_SBC_1	0.1111
p.A270V	DO229227	THCA	ICGC	VVSSS	DEG_SPOP_SBC_1	0.1111
p.A270V	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	0.1111
p.A270V	SIDM01147	Gastric Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	0.1111
p.A270V	SIDM01650	Non-Cancerous	GDSC	VVSSS	DEG_SPOP_SBC_1	0.1111
p.Q266E	DO229248	THCA	ICGC	VVSSS	DEG_SPOP_SBC_1	0.2222
p.Q264H	DO229250	THCA	ICGC	VVSSS	DEG_SPOP_SBC_1	0.2778
p.S261C	SIDM01662	Plasma Cell Myeloma	GDSC	VVSSS	DEG_SPOP_SBC_1	0.7541
p.Y268C	ACH-000300	Kidney Cancer	CCLE	VVSSS	DEG_SPOP_SBC_1	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12035	Keratin, type II cytoskeletal 3	DEG_SPOP_SBC_1	525:529	VVSSS	SPOP	0.6552	More...
P41180	Extracellular calcium-sensing receptor	DEG_SPOP_SBC_1	1055:1059	VVSSS	SPOP	0.8121	More...
Q14525	Keratin, type I cuticular Ha3-II	DEG_SPOP_SBC_1	258:262	VVSSS	SPOP	0.5895	More...
Q5UIP0	Telomere-associated protein RIF1	DEG_SPOP_SBC_1	1196:1200	VVSSS	SPOP	0.8866	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	197:201	VVSSS	SPOP	0.913	More...
Q96JH7	Deubiquitinating protein VCPIP1	DEG_SPOP_SBC_1	1143:1147	VVSSS	SPOP	0.9956	More...
Q9H2K2	Poly [ADP-ribose] polymerase tankyrase-2	DEG_SPOP_SBC_1	854:858	VVSSS	SPOP	0.9829	More...
Q9P243	Zinc finger protein ZFAT	DEG_SPOP_SBC_1	581:585	VVSSS	SPOP	0.9599	More...
Q9P2N6	KAT8 regulatory NSL complex subunit 3	DEG_SPOP_SBC_1	715:719	VVSSS	SPOP	0.9927	More...
O60279	Sushi domain-containing protein 5	DEG_SPOP_SBC_1	362:366	VVSSS	SPOP	0.9462	More...
Q96K58	Zinc finger protein 668	DEG_SPOP_SBC_1	402:406	VVSSS	SPOP	0.9427	More...
Q9BQN1	Protein FAM83C	DEG_SPOP_SBC_1	376:380	VVSSS	SPOP	0.9887	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons