DegronMD

Uniprot ID: Q96K58

Source protein: Zinc finger protein 668

Source gene: ZNF668

Class: DEG_SPOP_SBC_1

Location: 402:406

E3 ligase: SPOP

DEGRON score: 0.9427

ASA_SCORE: 67.9

COIL: 0.7744

CONS_SCORE: 0.7395

DSS_SCORE: 0.3554

HELIX: 0.0918

FCONS_SCORE: 0.9446

RIG_SCORE: 0.727

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A397S	TCGA-49-AAR3	LUAD	TCGA	VVSSS	DEG_SPOP_SBC_1	0.1944
p.A400P	TCGA-CK-4951	COAD	TCGA	VVSSS	DEG_SPOP_SBC_1	0.2778
p.G393R	TCGA-DF-A2KN	UCEC	TCGA	VVSSS	DEG_SPOP_SBC_1	0.0833
p.S410L	TCGA-E2-A15H	BRCA	TCGA	VVSSS	DEG_SPOP_SBC_1	0.2222
p.H393Y	DO37778	SKCM	ICGC	VVSSS	DEG_SPOP_SBC_1	0.0833
p.C394Y	DO222381	STAD	ICGC	VVSSS	DEG_SPOP_SBC_1	0.1111
p.A396T	DO48172	UCEC	ICGC	VVSSS	DEG_SPOP_SBC_1	0.1667
p.R408G	DO223282	UCEC	ICGC	VVSSS	DEG_SPOP_SBC_1	0.2778
p.K399T	DO41211	UCEC	ICGC	VVSSS	DEG_SPOP_SBC_1	0.3611
p.R413H	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VVSSS	DEG_SPOP_SBC_1	0.1389
p.R413H	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	VVSSS	DEG_SPOP_SBC_1	0.1389
p.A395V	SIDM01233	Colorectal Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	0.1389
p.A395V	C2BBe1	large_intestine	COSMIC	VVSSS	DEG_SPOP_SBC_1	0.1389
p.R399H	SIDM01413	Oral Cavity Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	0.3611
p.K399R	ACH-000995	Leukemia	CCLE	VVSSS	DEG_SPOP_SBC_1	0.3611
p.K399R	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	VVSSS	DEG_SPOP_SBC_1	0.3611

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12035	Keratin, type II cytoskeletal 3	DEG_SPOP_SBC_1	525:529	VVSSS	SPOP	0.6552	More...
P41180	Extracellular calcium-sensing receptor	DEG_SPOP_SBC_1	1055:1059	VVSSS	SPOP	0.8121	More...
Q14525	Keratin, type I cuticular Ha3-II	DEG_SPOP_SBC_1	258:262	VVSSS	SPOP	0.5895	More...
Q5UIP0	Telomere-associated protein RIF1	DEG_SPOP_SBC_1	1196:1200	VVSSS	SPOP	0.8866	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	197:201	VVSSS	SPOP	0.913	More...
Q96JH7	Deubiquitinating protein VCPIP1	DEG_SPOP_SBC_1	1143:1147	VVSSS	SPOP	0.9956	More...
Q9H2K2	Poly [ADP-ribose] polymerase tankyrase-2	DEG_SPOP_SBC_1	854:858	VVSSS	SPOP	0.9829	More...
Q9P243	Zinc finger protein ZFAT	DEG_SPOP_SBC_1	581:585	VVSSS	SPOP	0.9599	More...
Q9P2N6	KAT8 regulatory NSL complex subunit 3	DEG_SPOP_SBC_1	715:719	VVSSS	SPOP	0.9927	More...
O60279	Sushi domain-containing protein 5	DEG_SPOP_SBC_1	362:366	VVSSS	SPOP	0.9462	More...
Q96K58	Zinc finger protein 668	DEG_SPOP_SBC_1	402:406	VVSSS	SPOP	0.9427	More...
Q9BQN1	Protein FAM83C	DEG_SPOP_SBC_1	376:380	VVSSS	SPOP	0.9887	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons