DegronMD

Uniprot ID: Q9P243

Source protein: Zinc finger protein ZFAT

Source gene: ZFAT

Class: DEG_SPOP_SBC_1

Location: 581:585

E3 ligase: SPOP

DEGRON score: 0.9599

ASA_SCORE: 70.2

COIL: 0.751

CONS_SCORE: 0.2621

DSS_SCORE: 0.4883

HELIX: 0.0414

FCONS_SCORE: 0.9618

RIG_SCORE: 0.7268

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S584P	TCGA-5P-A9JY	KIRP	TCGA	VVSSS	DEG_SPOP_SBC_1	0.6752
p.C575F	TCGA-85-6561	LUSC	TCGA	VVSSS	DEG_SPOP_SBC_1	0.1667
p.V592M	TCGA-B5-A1MX	UCEC	TCGA	VVSSS	DEG_SPOP_SBC_1	0.1389
p.A571V	TCGA-D1-A177	UCEC	TCGA	VVSSS	DEG_SPOP_SBC_1	0.0556
p.L587F	DO14526	HNSC	ICGC	VVSSS	DEG_SPOP_SBC_1	0.2778
p.S572P	DO223944	KIRP	ICGC	VVSSS	DEG_SPOP_SBC_1	0.0833
p.S592F	DO229187	LMS	ICGC	VVSSS	DEG_SPOP_SBC_1	0.1389
p.A594T	DO46657	PAAD	ICGC	VVSSS	DEG_SPOP_SBC_1	0.0833
p.A594T	DO219774	UCEC	ICGC	VVSSS	DEG_SPOP_SBC_1	0.0833
p.A594T	SNU-1040	large_intestine	COSMIC	VVSSS	DEG_SPOP_SBC_1	0.0833
p.V580M	DO218850	SKCA	ICGC	VVSSS	DEG_SPOP_SBC_1	0.3056
p.V580M	DO41999	UCEC	ICGC	VVSSS	DEG_SPOP_SBC_1	0.3056
p.V581M	SIDM00143	Small Cell Lung Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	0.7208
p.V581M	SIDM00068	Colorectal Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	0.7208
p.V581M	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	0.7208
p.V581M	SIDM00628	Breast Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	0.7208
p.F585I	NCI-H510A	lung	COSMIC	VVSSS	DEG_SPOP_SBC_1	0.7415
p.A579S	H2369	pleura	COSMIC	VVSSS	DEG_SPOP_SBC_1	0.2778
p.A579V	SNU-175	large_intestine	COSMIC	VVSSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12035	Keratin, type II cytoskeletal 3	DEG_SPOP_SBC_1	525:529	VVSSS	SPOP	0.6552	More...
P41180	Extracellular calcium-sensing receptor	DEG_SPOP_SBC_1	1055:1059	VVSSS	SPOP	0.8121	More...
Q14525	Keratin, type I cuticular Ha3-II	DEG_SPOP_SBC_1	258:262	VVSSS	SPOP	0.5895	More...
Q5UIP0	Telomere-associated protein RIF1	DEG_SPOP_SBC_1	1196:1200	VVSSS	SPOP	0.8866	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	197:201	VVSSS	SPOP	0.913	More...
Q96JH7	Deubiquitinating protein VCPIP1	DEG_SPOP_SBC_1	1143:1147	VVSSS	SPOP	0.9956	More...
Q9H2K2	Poly [ADP-ribose] polymerase tankyrase-2	DEG_SPOP_SBC_1	854:858	VVSSS	SPOP	0.9829	More...
Q9P243	Zinc finger protein ZFAT	DEG_SPOP_SBC_1	581:585	VVSSS	SPOP	0.9599	More...
Q9P2N6	KAT8 regulatory NSL complex subunit 3	DEG_SPOP_SBC_1	715:719	VVSSS	SPOP	0.9927	More...
O60279	Sushi domain-containing protein 5	DEG_SPOP_SBC_1	362:366	VVSSS	SPOP	0.9462	More...
Q96K58	Zinc finger protein 668	DEG_SPOP_SBC_1	402:406	VVSSS	SPOP	0.9427	More...
Q9BQN1	Protein FAM83C	DEG_SPOP_SBC_1	376:380	VVSSS	SPOP	0.9887	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons