DegronMD - Q9BQN1(FAM83C)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P515L	TCGA-18-3409	LUSC	TCGA	SRGQLDLLV	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.25
p.P515L	DO26444	LUSC	ICGC	SRGQLDLLV	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.25
p.P366L	TCGA-56-8083	LUSC	TCGA	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0556
p.P366L	DO223723	LUSC	ICGC	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0556
p.M357K	TCGA-66-2742	LUSC	TCGA	PSSTS	DEG_SPOP_SBC_1	343:347	Mutation rewiring degron network	0.0556
p.M357K	DO26439	LUSC	ICGC	PSSTS	DEG_SPOP_SBC_1	343:347	Mutation rewiring degron network	0.0556
p.V335F	TCGA-73-4666	LUAD	TCGA	PSSTS	DEG_SPOP_SBC_1	343:347	Mutation rewiring degron network	0.1111
p.V335F	DO26230	LUAD	ICGC	PSSTS	DEG_SPOP_SBC_1	343:347	Mutation rewiring degron network	0.1111
p.P501S	TCGA-96-A4JK	LUSC	TCGA	SRGQLDLLV	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.25
p.P501S	DO45442	LUSC	ICGC	SRGQLDLLV	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.25
p.V335I	TCGA-B0-5113	KIRC	TCGA	PSSTS	DEG_SPOP_SBC_1	343:347	Mutation rewiring degron network	0.1111
p.V335I	DO17858	KIRC	ICGC	PSSTS	DEG_SPOP_SBC_1	343:347	Mutation rewiring degron network	0.1111
p.R385S	TCGA-BJ-A191	THCA	TCGA	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.1944
p.R385S	DO40167	THCA	ICGC	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.1944
p.G521E	TCGA-EE-A2MC	SKCM	TCGA	SRGQLDLLV	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.0833
p.G521E	DO220886	MELA	ICGC	SRGQLDLLV	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.0833
p.G521E	DO37559	SKCM	ICGC	SRGQLDLLV	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.0833
p.S379L	TCGA-FW-A3R5	SKCM	TCGA	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation altering degron motif	0.7667
p.S379L	DO37406	SKCM	ICGC	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation altering degron motif	0.7667
p.I351M	TCGA-VS-A94Z	CESC	TCGA	PSSTS	DEG_SPOP_SBC_1	343:347	Mutation rewiring degron network	0.2222
p.I351M	DO51634	CESC	ICGC	PSSTS	DEG_SPOP_SBC_1	343:347	Mutation rewiring degron network	0.2222
p.P355L	TCGA-WS-AB45	COAD	TCGA	PSSTS	DEG_SPOP_SBC_1	343:347	Mutation rewiring degron network	0.1111
p.P355L	DO51734	COAD	ICGC	PSSTS	DEG_SPOP_SBC_1	343:347	Mutation rewiring degron network	0.1111
p.P355L	DO52473	COCA	ICGC	PSSTS	DEG_SPOP_SBC_1	343:347	Mutation rewiring degron network	0.1111
p.A499E	DO229028	LICA	ICGC	SRGQLDLLV	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.1944
p.E519Q	DO48681	LIRI	ICGC	SRGQLDLLV	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.1389
p.S350I	DO23542	LIRI	ICGC	PSSTS	DEG_SPOP_SBC_1	343:347	Mutation rewiring degron network	0.25
p.P355S	DO220883	MELA	ICGC	PSSTS	DEG_SPOP_SBC_1	343:347	Mutation rewiring degron network	0.1111
p.S340L	DO222653	MELA	ICGC	PSSTS	DEG_SPOP_SBC_1	343:347	Mutation rewiring degron network	0.25
p.L356V	DO50727	ORCA	ICGC	PSSTS	DEG_SPOP_SBC_1	343:347	Mutation rewiring degron network	0.0833
p.A517V	DO232224	PBCA	ICGC	SRGQLDLLV	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.1944
p.R385C	SIDM02015	Colorectal Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.1944
p.R385H	SIDM00437	Acute Myeloid Leukemia	GDSC	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.1944
p.R385H	SIDM00383	Gastric Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.1944
p.R385H	SIDM00368	Small Cell Lung Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.1944
p.R385H	SIDM01622	Breast Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.1944
p.R385H	ACH-001574	Leukemia	CCLE	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.1944
p.R385H	SBC-5	lung	COSMIC	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.1944
p.R385H	SCH	stomach	COSMIC	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.1944
p.R385H	MOLM-13	haematopoietic and lymphoid tissue	COSMIC	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.1944
p.T339K	SIDM00759	Non-Small Cell Lung Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	343:347	Mutation rewiring degron network	0.2222
p.V520M	SIDM00660	Colorectal Carcinoma	GDSC	SRGQLDLLV	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.1111
p.V520M	SIDM00732	Glioblastoma	GDSC	SRGQLDLLV	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.1111
p.G369S	SIDM00449	B-Lymphoblastic Leukemia	GDSC	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.1389
p.G369S	ACH-000922	Leukemia	CCLE	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.1389
p.G369S	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.1389
p.S345N	SIDM00954	Breast Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	343:347	Mutation altering degron motif	0.7069
p.S345N	ACH-001820	Breast Cancer	CCLE	PSSTS	DEG_SPOP_SBC_1	343:347	Mutation altering degron motif	0.7069
p.S345N	COLO-824	breast	COSMIC	PSSTS	DEG_SPOP_SBC_1	343:347	Mutation altering degron motif	0.7069
p.T374M	SIDM00192	Colorectal Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.2778
p.T374M	SIDM01368	Gastric Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.2778
p.T374M	SIDM01442	Glioma	GDSC	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.2778
p.T374M	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.2778
p.S379T	ACH-000975	Lung Cancer	CCLE	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation altering degron motif	0.6005
p.L381V	ACH-001393	Breast Cancer	CCLE	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM83C

UniProt ID: Q9BQN1

Entrez ID: 128876

Protein name: Protein FAM83C

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM83C in