DegronMD - Q9BQN1(FAM83C)

FUNCTION: May play a role in MAPK signaling. {ECO:0000303|PubMed:24736947}.

GO - Biological processes (BP): signal transduction [GO:0007165]

GO - Molecular function (MF): protein kinase binding [GO:0019901]

GO - Cellular component (CC):

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Show entries

Search:

Degron hit	Class	E3 ligase	Source protein	Location	Detail
SRGQLDLLV	DEG_APCC_DBOX_1	APC,CDC20,FZR1	Protein FAM83C	504:512	More..
PSSTS	DEG_SPOP_SBC_1	SPOP	Protein FAM83C	343:347	More..
VVSSS	DEG_SPOP_SBC_1	SPOP	Protein FAM83C	376:380	More..

Showing 1 to 3 of 3 entries

Previous1Next

Show entries

Search:

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S379L	TCGA-FW-A3R5	SKCM	TCGA	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation altering degron motif	0.7667
p.S379L	DO37406	SKCM	ICGC	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation altering degron motif	0.7667
p.S345N	SIDM00954	Breast Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	343:347	Mutation altering degron motif	0.7069
p.S345N	ACH-001820	Breast Cancer	CCLE	PSSTS	DEG_SPOP_SBC_1	343:347	Mutation altering degron motif	0.7069
p.S345N	COLO-824	breast	COSMIC	PSSTS	DEG_SPOP_SBC_1	343:347	Mutation altering degron motif	0.7069
p.S379T	ACH-000975	Lung Cancer	CCLE	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation altering degron motif	0.6005
p.L381V	ACH-001393	Breast Cancer	CCLE	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.3056
p.T374M	SIDM00192	Colorectal Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.2778
p.T374M	SIDM01368	Gastric Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.2778
p.T374M	SIDM01442	Glioma	GDSC	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.2778
p.T374M	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.2778
p.P515L	TCGA-18-3409	LUSC	TCGA	SRGQLDLLV	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.25
p.P515L	DO26444	LUSC	ICGC	SRGQLDLLV	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.25
p.P501S	TCGA-96-A4JK	LUSC	TCGA	SRGQLDLLV	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.25
p.P501S	DO45442	LUSC	ICGC	SRGQLDLLV	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.25
p.S350I	DO23542	LIRI	ICGC	PSSTS	DEG_SPOP_SBC_1	343:347	Mutation rewiring degron network	0.25
p.S340L	DO222653	MELA	ICGC	PSSTS	DEG_SPOP_SBC_1	343:347	Mutation rewiring degron network	0.25
p.I351M	TCGA-VS-A94Z	CESC	TCGA	PSSTS	DEG_SPOP_SBC_1	343:347	Mutation rewiring degron network	0.2222
p.I351M	DO51634	CESC	ICGC	PSSTS	DEG_SPOP_SBC_1	343:347	Mutation rewiring degron network	0.2222
p.T339K	SIDM00759	Non-Small Cell Lung Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	343:347	Mutation rewiring degron network	0.2222

Showing 1 to 20 of 55 entries

Previous1 2 3Next

No drug screening data available for this protein.

No resistance data available for this Degron.

Kaplan plot for FAM83C in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM83C

UniProt ID: Q9BQN1

Entrez ID: 128876

Protein name: Protein FAM83C

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

No drug screening data available for this protein.

No resistance data available for this Degron.

Kaplan plot for FAM83C in