DegronMD

Uniprot ID: Q9BQN1

Source protein: Protein FAM83C

Source gene: FAM83C

Class: DEG_APCC_DBOX_1

Location: 504:512

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7611

ASA_SCORE: 82.5222

COIL: 0.8036

CONS_SCORE: 0.3092

DSS_SCORE: 0.6382

HELIX: 0.1048

FCONS_SCORE: 0.9885

RIG_SCORE: 0.7153

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P515L	TCGA-18-3409	LUSC	TCGA	SRGQLDLLV	DEG_APCC_DBOX_1	0.25
p.P515L	DO26444	LUSC	ICGC	SRGQLDLLV	DEG_APCC_DBOX_1	0.25
p.P501S	TCGA-96-A4JK	LUSC	TCGA	SRGQLDLLV	DEG_APCC_DBOX_1	0.25
p.P501S	DO45442	LUSC	ICGC	SRGQLDLLV	DEG_APCC_DBOX_1	0.25
p.G521E	TCGA-EE-A2MC	SKCM	TCGA	SRGQLDLLV	DEG_APCC_DBOX_1	0.0833
p.G521E	DO220886	MELA	ICGC	SRGQLDLLV	DEG_APCC_DBOX_1	0.0833
p.G521E	DO37559	SKCM	ICGC	SRGQLDLLV	DEG_APCC_DBOX_1	0.0833
p.A499E	DO229028	LICA	ICGC	SRGQLDLLV	DEG_APCC_DBOX_1	0.1944
p.E519Q	DO48681	LIRI	ICGC	SRGQLDLLV	DEG_APCC_DBOX_1	0.1389
p.A517V	DO232224	PBCA	ICGC	SRGQLDLLV	DEG_APCC_DBOX_1	0.1944
p.V520M	SIDM00660	Colorectal Carcinoma	GDSC	SRGQLDLLV	DEG_APCC_DBOX_1	0.1111
p.V520M	SIDM00732	Glioblastoma	GDSC	SRGQLDLLV	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQN1	Protein FAM83C	DEG_APCC_DBOX_1	504:512	SRGQLDLLV	APC,CDC20,FZR1	0.7611	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons