DegronMD - Q9P243(ZFAT)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S584P	TCGA-5P-A9JY	KIRP	TCGA	VVSSS	DEG_SPOP_SBC_1	581:585	Mutation altering degron motif	0.6752
p.C575F	TCGA-85-6561	LUSC	TCGA	VVSSS	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.1667
p.V592M	TCGA-B5-A1MX	UCEC	TCGA	VVSSS	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.1389
p.A571V	TCGA-D1-A177	UCEC	TCGA	VVSSS	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.0556
p.L587F	DO14526	HNSC	ICGC	VVSSS	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.2778
p.S572P	DO223944	KIRP	ICGC	VVSSS	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.0833
p.S592F	DO229187	LMS	ICGC	VVSSS	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.1389
p.A594T	DO46657	PAAD	ICGC	VVSSS	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.0833
p.A594T	DO219774	UCEC	ICGC	VVSSS	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.0833
p.A594T	SNU-1040	large intestine	COSMIC	VVSSS	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.0833
p.V580M	DO218850	SKCA	ICGC	VVSSS	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.3056
p.V580M	DO41999	UCEC	ICGC	VVSSS	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.3056
p.V581M	SIDM00143	Small Cell Lung Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	581:585	Mutation altering degron motif	0.7208
p.V581M	SIDM00068	Colorectal Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	581:585	Mutation altering degron motif	0.7208
p.V581M	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	581:585	Mutation altering degron motif	0.7208
p.V581M	SIDM00628	Breast Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	581:585	Mutation altering degron motif	0.7208
p.F585I	NCI-H510A	lung	COSMIC	VVSSS	DEG_SPOP_SBC_1	581:585	Mutation altering degron motif	0.7415
p.A579S	H2369	pleura	COSMIC	VVSSS	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.2778
p.A579V	SNU-175	large intestine	COSMIC	VVSSS	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.2778

Kaplan plot for ZFAT in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZFAT

UniProt ID: Q9P243

Entrez ID: 57623

Protein name: Zinc finger protein ZFAT (Zinc finger gene in AITD susceptibility region) (Zinc finger protein 406)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZFAT in