DegronMD

Uniprot ID: O60279

Source protein: Sushi domain-containing protein 5

Source gene: SUSD5

Class: DEG_SPOP_SBC_1

Location: 362:366

E3 ligase: SPOP

DEGRON score: 0.9462

ASA_SCORE: 72.36

COIL: 0.785

CONS_SCORE: 0.6584

DSS_SCORE: 0.5938

HELIX: 0.046

FCONS_SCORE: 0.9811

RIG_SCORE: 0.6899

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K353M	TCGA-39-5031	LUSC	TCGA	VVSSS	DEG_SPOP_SBC_1	0.1944
p.K353M	DO26526	LUSC	ICGC	VVSSS	DEG_SPOP_SBC_1	0.1944
p.V362L	TCGA-A3-3374	KIRC	TCGA	VVSSS	DEG_SPOP_SBC_1	0.6765
p.P375H	TCGA-A5-A0G1	UCEC	TCGA	VVSSS	DEG_SPOP_SBC_1	0.0833
p.P375H	TCGA-G7-6797	KIRP	TCGA	VVSSS	DEG_SPOP_SBC_1	0.0833
p.P375H	DO20917	KIRP	ICGC	VVSSS	DEG_SPOP_SBC_1	0.0833
p.P375H	DO42472	UCEC	ICGC	VVSSS	DEG_SPOP_SBC_1	0.0833
p.D360Y	TCGA-A5-A1OF	UCEC	TCGA	VVSSS	DEG_SPOP_SBC_1	0.2778
p.D360Y	DO42568	UCEC	ICGC	VVSSS	DEG_SPOP_SBC_1	0.2778
p.P375S	DO222407	MELA	ICGC	VVSSS	DEG_SPOP_SBC_1	0.0833
p.A358T	SIDM00889	Cervical Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	0.2222
p.A358T	ACH-001333	Cervical Cancer	CCLE	VVSSS	DEG_SPOP_SBC_1	0.2222
p.A358T	C-33-A	cervix	COSMIC	VVSSS	DEG_SPOP_SBC_1	0.2222
p.S369F	SIDM01398	Melanoma	GDSC	VVSSS	DEG_SPOP_SBC_1	0.25
p.S369F	ACH-000661	Skin Cancer	CCLE	VVSSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12035	Keratin, type II cytoskeletal 3	DEG_SPOP_SBC_1	525:529	VVSSS	SPOP	0.6552	More...
P41180	Extracellular calcium-sensing receptor	DEG_SPOP_SBC_1	1055:1059	VVSSS	SPOP	0.8121	More...
Q14525	Keratin, type I cuticular Ha3-II	DEG_SPOP_SBC_1	258:262	VVSSS	SPOP	0.5895	More...
Q5UIP0	Telomere-associated protein RIF1	DEG_SPOP_SBC_1	1196:1200	VVSSS	SPOP	0.8866	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	197:201	VVSSS	SPOP	0.913	More...
Q96JH7	Deubiquitinating protein VCPIP1	DEG_SPOP_SBC_1	1143:1147	VVSSS	SPOP	0.9956	More...
Q9H2K2	Poly [ADP-ribose] polymerase tankyrase-2	DEG_SPOP_SBC_1	854:858	VVSSS	SPOP	0.9829	More...
Q9P243	Zinc finger protein ZFAT	DEG_SPOP_SBC_1	581:585	VVSSS	SPOP	0.9599	More...
Q9P2N6	KAT8 regulatory NSL complex subunit 3	DEG_SPOP_SBC_1	715:719	VVSSS	SPOP	0.9927	More...
O60279	Sushi domain-containing protein 5	DEG_SPOP_SBC_1	362:366	VVSSS	SPOP	0.9462	More...
Q96K58	Zinc finger protein 668	DEG_SPOP_SBC_1	402:406	VVSSS	SPOP	0.9427	More...
Q9BQN1	Protein FAM83C	DEG_SPOP_SBC_1	376:380	VVSSS	SPOP	0.9887	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons