DegronMD

Uniprot ID: Q8NDX5

Source protein: Polyhomeotic-like protein 3

Source gene: PHC3

Class: DEG_SPOP_SBC_1

Location: 197:201

E3 ligase: SPOP

DEGRON score: 0.913

ASA_SCORE: 88.88

COIL: 0.9572

CONS_SCORE: 0.4526

DSS_SCORE: 0.2854

HELIX: 0.0146

FCONS_SCORE: 0.956

RIG_SCORE: 0.7016

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L187V	TCGA-90-7964	LUSC	TCGA	VVSSS	DEG_SPOP_SBC_1	0.0556
p.L187V	DO27046	LUSC	ICGC	VVSSS	DEG_SPOP_SBC_1	0.0556
p.A202V	TCGA-B5-A11E	UCEC	TCGA	VVSSS	DEG_SPOP_SBC_1	0.3056
p.A202V	DO41644	UCEC	ICGC	VVSSS	DEG_SPOP_SBC_1	0.3056
p.P196L	TCGA-E6-A1LZ	UCEC	TCGA	VVSSS	DEG_SPOP_SBC_1	0.3056
p.P196L	DO41398	UCEC	ICGC	VVSSS	DEG_SPOP_SBC_1	0.3056
p.L192M	DO228986	LICA	ICGC	VVSSS	DEG_SPOP_SBC_1	0.1944
p.S211L	DO232761	PBCA	ICGC	VVSSS	DEG_SPOP_SBC_1	0.0556
p.R188Q	SIDM00683	Prostate Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	0.0833
p.R188Q	ACH-000977	lymph_node	CCLE	VVSSS	DEG_SPOP_SBC_1	0.0833
p.R188Q	ACH-001369	Ovarian Cancer	CCLE	VVSSS	DEG_SPOP_SBC_1	0.0833
p.R188Q	LNCaP-Clone-FGC	prostate	COSMIC	VVSSS	DEG_SPOP_SBC_1	0.0833
p.Q198E	JHH-1	liver	COSMIC	VVSSS	DEG_SPOP_SBC_1	0.6744
p.Q200H	LAN-6	autonomic_ganglia	COSMIC	VVSSS	DEG_SPOP_SBC_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12035	Keratin, type II cytoskeletal 3	DEG_SPOP_SBC_1	525:529	VVSSS	SPOP	0.6552	More...
P41180	Extracellular calcium-sensing receptor	DEG_SPOP_SBC_1	1055:1059	VVSSS	SPOP	0.8121	More...
Q14525	Keratin, type I cuticular Ha3-II	DEG_SPOP_SBC_1	258:262	VVSSS	SPOP	0.5895	More...
Q5UIP0	Telomere-associated protein RIF1	DEG_SPOP_SBC_1	1196:1200	VVSSS	SPOP	0.8866	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	197:201	VVSSS	SPOP	0.913	More...
Q96JH7	Deubiquitinating protein VCPIP1	DEG_SPOP_SBC_1	1143:1147	VVSSS	SPOP	0.9956	More...
Q9H2K2	Poly [ADP-ribose] polymerase tankyrase-2	DEG_SPOP_SBC_1	854:858	VVSSS	SPOP	0.9829	More...
Q9P243	Zinc finger protein ZFAT	DEG_SPOP_SBC_1	581:585	VVSSS	SPOP	0.9599	More...
Q9P2N6	KAT8 regulatory NSL complex subunit 3	DEG_SPOP_SBC_1	715:719	VVSSS	SPOP	0.9927	More...
O60279	Sushi domain-containing protein 5	DEG_SPOP_SBC_1	362:366	VVSSS	SPOP	0.9462	More...
Q96K58	Zinc finger protein 668	DEG_SPOP_SBC_1	402:406	VVSSS	SPOP	0.9427	More...
Q9BQN1	Protein FAM83C	DEG_SPOP_SBC_1	376:380	VVSSS	SPOP	0.9887	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons