DegronMD

Uniprot ID: Q9P2N6

Source protein: KAT8 regulatory NSL complex subunit 3

Source gene: KANSL3

Class: DEG_SCF_FBW7_1

Location: 785:791

E3 ligase: FBXW7

DEGRON score: 0.9602

ASA_SCORE: 93.9429

COIL: 0.929

CONS_SCORE: 0.4658

DSS_SCORE: 0.5218

HELIX: 0.0296

FCONS_SCORE: 1.0512

RIG_SCORE: 0.721

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I780V	TCGA-AA-A01R	COAD	TCGA	LPTPMQS	DEG_SCF_FBW7_1	0.1944
p.I780V	DO7934	COAD	ICGC	LPTPMQS	DEG_SCF_FBW7_1	0.1944
p.A791V	TCGA-BR-4361	STAD	TCGA	LPTPMQS	DEG_SCF_FBW7_1	0.6936
p.A791V	DO38887	STAD	ICGC	LPTPMQS	DEG_SCF_FBW7_1	0.6936
p.G795W	TCGA-D3-A2JO	SKCM	TCGA	LPTPMQS	DEG_SCF_FBW7_1	0.2222
p.G795W	DO47619	SKCM	ICGC	LPTPMQS	DEG_SCF_FBW7_1	0.2222
p.G794D	TCGA-DU-5851	LGG	TCGA	LPTPMQS	DEG_SCF_FBW7_1	0.25
p.G794D	DO22768	LGG	ICGC	LPTPMQS	DEG_SCF_FBW7_1	0.25
p.P793L	TCGA-DX-AB2E	SARC	TCGA	LPTPMQS	DEG_SCF_FBW7_1	0.2778
p.P793L	DO220073	SARC	ICGC	LPTPMQS	DEG_SCF_FBW7_1	0.2778
p.R778C	TCGA-EE-A2GO	SKCM	TCGA	LPTPMQS	DEG_SCF_FBW7_1	0.1389
p.R778C	DO37823	SKCM	ICGC	LPTPMQS	DEG_SCF_FBW7_1	0.1389
p.G794R	TCGA-KQ-A41S	BLCA	TCGA	LPTPMQS	DEG_SCF_FBW7_1	0.25
p.G794R	DO223593	BLCA	ICGC	LPTPMQS	DEG_SCF_FBW7_1	0.25
p.R778L	DO233206	GACA	ICGC	LPTPMQS	DEG_SCF_FBW7_1	0.1389
p.G790V	DO228819	LICA	ICGC	LPTPMQS	DEG_SCF_FBW7_1	0.7532
p.T779N	DO229028	LICA	ICGC	LPTPMQS	DEG_SCF_FBW7_1	0.1667
p.S787F	DO222843	MELA	ICGC	LPTPMQS	DEG_SCF_FBW7_1	0.7982
p.T792A	SIDM00507	Other Solid Cancers	GDSC	LPTPMQS	DEG_SCF_FBW7_1	0.3056
p.T792A	ACH-001490	Lung Cancer	CCLE	LPTPMQS	DEG_SCF_FBW7_1	0.3056
p.T792A	COR-L321	NS	COSMIC	LPTPMQS	DEG_SCF_FBW7_1	0.3056
p.L786F	SIDM00523	Small Cell Lung Carcinoma	GDSC	LPTPMQS	DEG_SCF_FBW7_1	0.6981
p.L786F	ACH-000698	Lung Cancer	CCLE	LPTPMQS	DEG_SCF_FBW7_1	0.6981
p.L786F	DMS-53	lung	COSMIC	LPTPMQS	DEG_SCF_FBW7_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2N6	KAT8 regulatory NSL complex subunit 3	DEG_SCF_FBW7_1	785:791	LPTPMQS	FBXW7	0.9602	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons