DegronMD

Uniprot ID: Q5UIP0

Source protein: Telomere-associated protein RIF1

Source gene: RIF1

Class: DEG_APCC_KENBOX_2

Location: 1433:1437

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9624

ASA_SCORE: 107.12

COIL: 0.6376

CONS_SCORE: 0.3293

DSS_SCORE: 0.7225

HELIX: 0.3528

FCONS_SCORE: 1.0758

RIG_SCORE: 0.5704

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1444H	TCGA-16-0848	GBM	TCGA	DKENS	DEG_APCC_KENBOX_2	0.1389
p.R1444H	DO12196	GBM	ICGC	DKENS	DEG_APCC_KENBOX_2	0.1389
p.S1431N	TCGA-73-4668	LUAD	TCGA	DKENS	DEG_APCC_KENBOX_2	0.7222
p.S1431N	DO23961	LUAD	ICGC	DKENS	DEG_APCC_KENBOX_2	0.7222
p.N1436T	TCGA-B5-A11E	UCEC	TCGA	DKENS	DEG_APCC_KENBOX_2	0.7055
p.N1436T	DO41644	UCEC	ICGC	DKENS	DEG_APCC_KENBOX_2	0.7055
p.D1433Y	TCGA-BR-4256	STAD	TCGA	DKENS	DEG_APCC_KENBOX_2	0.6214
p.D1433Y	DO38743	STAD	ICGC	DKENS	DEG_APCC_KENBOX_2	0.6214
p.D1433H	DO224905	BRCA	ICGC	DKENS	DEG_APCC_KENBOX_2	0.6577
p.R1444G	DO50403	ESAD	ICGC	DKENS	DEG_APCC_KENBOX_2	0.1389
p.R1443L	DO229025	LICA	ICGC	DKENS	DEG_APCC_KENBOX_2	0.1667
p.K1445N	SIDM01963	Colorectal Carcinoma	GDSC	DKENS	DEG_APCC_KENBOX_2	0.2222
p.E1430G	SIDM01090	Colorectal Carcinoma	GDSC	DKENS	DEG_APCC_KENBOX_2	0.25
p.E1430G	ACH-000943	Colon/Colorectal Cancer	CCLE	DKENS	DEG_APCC_KENBOX_2	0.25
p.E1430G	RKO	large_intestine	COSMIC	DKENS	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	DEG_APCC_KENBOX_2	509:513	DKENS	APC,CDC20,FZR1	0.5073	More...
Q5UIP0	Telomere-associated protein RIF1	DEG_APCC_KENBOX_2	1433:1437	DKENS	APC,CDC20,FZR1	0.9624	More...
Q9UIG0	Tyrosine-protein kinase BAZ1B	DEG_APCC_KENBOX_2	162:166	DKENS	APC,CDC20,FZR1	0.9945	More...
Q7RTY8	Transmembrane protease serine 7	DEG_APCC_KENBOX_2	2:6	DKENS	APC,CDC20,FZR1	0.6245	More...
Q5JPF3	Ankyrin repeat domain-containing protein 36C	DEG_APCC_KENBOX_2	966:970	DKENS	APC,CDC20,FZR1	0.998	More...
Q8N323	NXPE family member 1	DEG_APCC_KENBOX_2	270:274	DKENS	APC,CDC20,FZR1	0.9694	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons