DegronMD

Uniprot ID: Q7RTY8

Source protein: Transmembrane protease serine 7

Source gene: TMPRSS7

Class: DEG_APCC_KENBOX_2

Location: 2:6

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6245

ASA_SCORE: 119.76

COIL: 0.8812

CONS_SCORE: 0.2619

DSS_SCORE: 0.859

HELIX: 0.1228

FCONS_SCORE: 1.0507

RIG_SCORE: 0.7084

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R3C	TCGA-A5-A2K5	UCEC	TCGA	DKENS	DEG_APCC_KENBOX_2	0.8301
p.R3C	TCGA-CA-6718	COAD	TCGA	DKENS	DEG_APCC_KENBOX_2	0.8301
p.R3C	TCGA-EI-6917	READ	TCGA	DKENS	DEG_APCC_KENBOX_2	0.8301
p.L10F	TCGA-AZ-4315	COAD	TCGA	DKENS	DEG_APCC_KENBOX_2	0.2222
p.E12K	TCGA-EO-A22X	UCEC	TCGA	DKENS	DEG_APCC_KENBOX_2	0.1667
p.D14Y	DO46779	PAEN	ICGC	DKENS	DEG_APCC_KENBOX_2	0.1111
p.I7T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	DKENS	DEG_APCC_KENBOX_2	0.3056
p.I7T	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	DKENS	DEG_APCC_KENBOX_2	0.3056
p.R3L	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	DKENS	DEG_APCC_KENBOX_2	0.8428
p.R3L	NCI-H1793	lung	COSMIC	DKENS	DEG_APCC_KENBOX_2	0.8428

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	DEG_APCC_KENBOX_2	509:513	DKENS	APC,CDC20,FZR1	0.5073	More...
Q5UIP0	Telomere-associated protein RIF1	DEG_APCC_KENBOX_2	1433:1437	DKENS	APC,CDC20,FZR1	0.9624	More...
Q9UIG0	Tyrosine-protein kinase BAZ1B	DEG_APCC_KENBOX_2	162:166	DKENS	APC,CDC20,FZR1	0.9945	More...
Q7RTY8	Transmembrane protease serine 7	DEG_APCC_KENBOX_2	2:6	DKENS	APC,CDC20,FZR1	0.6245	More...
Q5JPF3	Ankyrin repeat domain-containing protein 36C	DEG_APCC_KENBOX_2	966:970	DKENS	APC,CDC20,FZR1	0.998	More...
Q8N323	NXPE family member 1	DEG_APCC_KENBOX_2	270:274	DKENS	APC,CDC20,FZR1	0.9694	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons