DegronMD

Uniprot ID: Q8N323

Source protein: NXPE family member 1

Source gene: NXPE1

Class: DEG_APCC_KENBOX_2

Location: 270:274

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9694

ASA_SCORE: 63.7

COIL: 0.4186

CONS_SCORE: 0.3157

DSS_SCORE: 0.3687

HELIX: 0.5134

FCONS_SCORE: 1.2301

RIG_SCORE: 0.7734

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F263L	TCGA-A5-A0G1	UCEC	TCGA	DKENS	DEG_APCC_KENBOX_2	0.1389
p.R283W	TCGA-AX-A0J0	UCEC	TCGA	DKENS	DEG_APCC_KENBOX_2	0.0833
p.I272M	TCGA-BR-A4QL	STAD	TCGA	DKENS	DEG_APCC_KENBOX_2	0.7618
p.F266S	TCGA-CA-6718	COAD	TCGA	DKENS	DEG_APCC_KENBOX_2	0.2222
p.F266S	TCGA-XK-AAIW	PRAD	TCGA	DKENS	DEG_APCC_KENBOX_2	0.2222
p.P278R	TCGA-CN-6019	HNSC	TCGA	DKENS	DEG_APCC_KENBOX_2	0.2222
p.D275N	TCGA-D3-A8GL	SKCM	TCGA	DKENS	DEG_APCC_KENBOX_2	0.3056
p.R279Q	TCGA-EO-A3KX	UCEC	TCGA	DKENS	DEG_APCC_KENBOX_2	0.6389
p.E280K	TCGA-ER-A198	SKCM	TCGA	DKENS	DEG_APCC_KENBOX_2	0.2778
p.E280K	Sarc9371	bone	COSMIC	DKENS	DEG_APCC_KENBOX_2	0.2778
p.D270Y	DO4377	BRCA	ICGC	DKENS	DEG_APCC_KENBOX_2	0.6214
p.N273K	DO222755	COCA	ICGC	DKENS	DEG_APCC_KENBOX_2	0.6918
p.R261Q	DO13096	GBM	ICGC	DKENS	DEG_APCC_KENBOX_2	0.0833
p.S266Y	DO229029	LICA	ICGC	DKENS	DEG_APCC_KENBOX_2	0.2222
p.S279Y	DO49707	LIHC	ICGC	DKENS	DEG_APCC_KENBOX_2	0.6389
p.R278S	DO27620	LUSC	ICGC	DKENS	DEG_APCC_KENBOX_2	0.2222
p.S274N	DO222557	MELA	ICGC	DKENS	DEG_APCC_KENBOX_2	0.7069
p.V265I	DO36675	READ	ICGC	DKENS	DEG_APCC_KENBOX_2	0.1944
p.E272K	DO47100	RECA	ICGC	DKENS	DEG_APCC_KENBOX_2	0.7022
p.E272K	DO50299	SKCM	ICGC	DKENS	DEG_APCC_KENBOX_2	0.7022
p.G282E	DO47331	SKCM	ICGC	DKENS	DEG_APCC_KENBOX_2	0.1111
p.E272D	DO47837	STAD	ICGC	DKENS	DEG_APCC_KENBOX_2	0.6758
p.Y261H	SIDM02050	Colorectal Carcinoma	GDSC	DKENS	DEG_APCC_KENBOX_2	0.0833
p.I281T	SIDM00458	Acute Myeloid Leukemia	GDSC	DKENS	DEG_APCC_KENBOX_2	0.1389
p.I281T	SIDM00690	Head and Neck Carcinoma	GDSC	DKENS	DEG_APCC_KENBOX_2	0.1389
p.I281T	SIDM00849	Kidney Carcinoma	GDSC	DKENS	DEG_APCC_KENBOX_2	0.1389
p.I281T	SIDM00954	Breast Carcinoma	GDSC	DKENS	DEG_APCC_KENBOX_2	0.1389
p.I281T	SIDM00721	Small Cell Lung Carcinoma	GDSC	DKENS	DEG_APCC_KENBOX_2	0.1389
p.I281T	SIDM00720	Mesothelioma	GDSC	DKENS	DEG_APCC_KENBOX_2	0.1389
p.I281T	SIDM00808	Burkitt's Lymphoma	GDSC	DKENS	DEG_APCC_KENBOX_2	0.1389
p.I281T	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	DKENS	DEG_APCC_KENBOX_2	0.1389
p.I281T	SIDM01387	Small Cell Lung Carcinoma	GDSC	DKENS	DEG_APCC_KENBOX_2	0.1389
p.I281T	SIDM01254	Burkitt's Lymphoma	GDSC	DKENS	DEG_APCC_KENBOX_2	0.1389
p.I272T	SIDM00945	Colorectal Carcinoma	GDSC	DKENS	DEG_APCC_KENBOX_2	0.7078
p.D275H	SIDM00724	Non-Small Cell Lung Carcinoma	GDSC	DKENS	DEG_APCC_KENBOX_2	0.3056
p.D275H	ACH-000121	Lung Cancer	CCLE	DKENS	DEG_APCC_KENBOX_2	0.3056
p.D275H	NCI-H2405	lung	COSMIC	DKENS	DEG_APCC_KENBOX_2	0.3056
p.P262S	Sarc9371	bone	COSMIC	DKENS	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	DEG_APCC_KENBOX_2	509:513	DKENS	APC,CDC20,FZR1	0.5073	More...
Q5UIP0	Telomere-associated protein RIF1	DEG_APCC_KENBOX_2	1433:1437	DKENS	APC,CDC20,FZR1	0.9624	More...
Q9UIG0	Tyrosine-protein kinase BAZ1B	DEG_APCC_KENBOX_2	162:166	DKENS	APC,CDC20,FZR1	0.9945	More...
Q7RTY8	Transmembrane protease serine 7	DEG_APCC_KENBOX_2	2:6	DKENS	APC,CDC20,FZR1	0.6245	More...
Q5JPF3	Ankyrin repeat domain-containing protein 36C	DEG_APCC_KENBOX_2	966:970	DKENS	APC,CDC20,FZR1	0.998	More...
Q8N323	NXPE family member 1	DEG_APCC_KENBOX_2	270:274	DKENS	APC,CDC20,FZR1	0.9694	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DKENS

Degron related mutations and impact score

Drug responses associated with NXPE1 mutations

All proteins holding degron of DKENS