DegronMD

Uniprot ID: P48736

Source protein: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Source gene: PIK3CG

Class: DEG_APCC_KENBOX_2

Location: 509:513

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5073

ASA_SCORE: 49.52

COIL: 0.687

CONS_SCORE: 0.3916

DSS_SCORE: 0.476

HELIX: 0.0966

FCONS_SCORE: 0.8145

RIG_SCORE: 0.6844

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T503K	TCGA-96-7544	LUSC	TCGA	DKENS	DEG_APCC_KENBOX_2	0.1667
p.T503K	DO26425	LUSC	ICGC	DKENS	DEG_APCC_KENBOX_2	0.1667
p.E511D	TCGA-AA-A010	COAD	TCGA	DKENS	DEG_APCC_KENBOX_2	0.6758
p.L519I	TCGA-AJ-A3EL	UCEC	TCGA	DKENS	DEG_APCC_KENBOX_2	0.1667
p.L519I	DO41542	UCEC	ICGC	DKENS	DEG_APCC_KENBOX_2	0.1667
p.N512K	TCGA-D6-A4ZB	HNSC	TCGA	DKENS	DEG_APCC_KENBOX_2	0.6918
p.N512K	DO44446	HNSC	ICGC	DKENS	DEG_APCC_KENBOX_2	0.6918
p.N522S	DO229013	COCA	ICGC	DKENS	DEG_APCC_KENBOX_2	0.0833
p.L520Q	DO231992	LICA	ICGC	DKENS	DEG_APCC_KENBOX_2	0.1389
p.S515P	SIDM00216	Colorectal Carcinoma	GDSC	DKENS	DEG_APCC_KENBOX_2	0.2778
p.S515P	ACH-000989	Colon/Colorectal Cancer	CCLE	DKENS	DEG_APCC_KENBOX_2	0.2778
p.S515P	SNU-175	large_intestine	COSMIC	DKENS	DEG_APCC_KENBOX_2	0.2778
p.E511K	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	DKENS	DEG_APCC_KENBOX_2	0.7022
p.E511K	ACH-000904	Lung Cancer	CCLE	DKENS	DEG_APCC_KENBOX_2	0.7022
p.E511K	ACH-001362	Lung Cancer	CCLE	DKENS	DEG_APCC_KENBOX_2	0.7022
p.E511K	NCI-H1770	lung	COSMIC	DKENS	DEG_APCC_KENBOX_2	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	DEG_APCC_KENBOX_2	509:513	DKENS	APC,CDC20,FZR1	0.5073	More...
Q5UIP0	Telomere-associated protein RIF1	DEG_APCC_KENBOX_2	1433:1437	DKENS	APC,CDC20,FZR1	0.9624	More...
Q9UIG0	Tyrosine-protein kinase BAZ1B	DEG_APCC_KENBOX_2	162:166	DKENS	APC,CDC20,FZR1	0.9945	More...
Q7RTY8	Transmembrane protease serine 7	DEG_APCC_KENBOX_2	2:6	DKENS	APC,CDC20,FZR1	0.6245	More...
Q5JPF3	Ankyrin repeat domain-containing protein 36C	DEG_APCC_KENBOX_2	966:970	DKENS	APC,CDC20,FZR1	0.998	More...
Q8N323	NXPE family member 1	DEG_APCC_KENBOX_2	270:274	DKENS	APC,CDC20,FZR1	0.9694	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons