DegronMD

Uniprot ID: Q9UIG0

Source protein: Tyrosine-protein kinase BAZ1B

Source gene: BAZ1B

Class: DEG_APCC_KENBOX_2

Location: 162:166

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9945

ASA_SCORE: 103.92

COIL: 0.7592

CONS_SCORE: 0.4762

DSS_SCORE: 0.7468

HELIX: 0.218

FCONS_SCORE: 1.1091

RIG_SCORE: 0.5739

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N165K	TCGA-A5-A0G2	UCEC	TCGA	DKENS	DEG_APCC_KENBOX_2	0.6918
p.N165K	DO41235	UCEC	ICGC	DKENS	DEG_APCC_KENBOX_2	0.6918
p.S161N	TCGA-AX-A063	UCEC	TCGA	DKENS	DEG_APCC_KENBOX_2	0.75
p.S161N	DO42201	UCEC	ICGC	DKENS	DEG_APCC_KENBOX_2	0.75
p.E164D	TCGA-B5-A3FC	UCEC	TCGA	DKENS	DEG_APCC_KENBOX_2	0.6758
p.E164D	DO41871	UCEC	ICGC	DKENS	DEG_APCC_KENBOX_2	0.6758
p.Q168E	TCGA-F7-8489	HNSC	TCGA	DKENS	DEG_APCC_KENBOX_2	0.2778
p.Q168E	DO14319	HNSC	ICGC	DKENS	DEG_APCC_KENBOX_2	0.2778
p.S166Y	TCGA-L5-A8NE	ESCA	TCGA	DKENS	DEG_APCC_KENBOX_2	0.712
p.G154C	DO233944	GACA	ICGC	DKENS	DEG_APCC_KENBOX_2	0.1111
p.G154C	DO35442	PACA	ICGC	DKENS	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	DEG_APCC_KENBOX_2	509:513	DKENS	APC,CDC20,FZR1	0.5073	More...
Q5UIP0	Telomere-associated protein RIF1	DEG_APCC_KENBOX_2	1433:1437	DKENS	APC,CDC20,FZR1	0.9624	More...
Q9UIG0	Tyrosine-protein kinase BAZ1B	DEG_APCC_KENBOX_2	162:166	DKENS	APC,CDC20,FZR1	0.9945	More...
Q7RTY8	Transmembrane protease serine 7	DEG_APCC_KENBOX_2	2:6	DKENS	APC,CDC20,FZR1	0.6245	More...
Q5JPF3	Ankyrin repeat domain-containing protein 36C	DEG_APCC_KENBOX_2	966:970	DKENS	APC,CDC20,FZR1	0.998	More...
Q8N323	NXPE family member 1	DEG_APCC_KENBOX_2	270:274	DKENS	APC,CDC20,FZR1	0.9694	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons