DegronMD

Uniprot ID: Q5JPF3

Source protein: Ankyrin repeat domain-containing protein 36C

Source gene: ANKRD36C

Class: DEG_APCC_KENBOX_2

Location: 966:970

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.998

ASA_SCORE: 111.28

COIL: 0.8304

CONS_SCORE: 0.4137

DSS_SCORE: 0.6786

HELIX: 0.133

FCONS_SCORE: 1.1642

RIG_SCORE: 0.6295

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M974L	SIDM00216	Colorectal Carcinoma	GDSC	DKENS	DEG_APCC_KENBOX_2	0.2222
p.M974L	ACH-000989	Colon/Colorectal Cancer	CCLE	DKENS	DEG_APCC_KENBOX_2	0.2222
p.M974L	SNU-175	large_intestine	COSMIC	DKENS	DEG_APCC_KENBOX_2	0.2222
p.H956Q	SIDM00680	Colorectal Carcinoma	GDSC	DKENS	DEG_APCC_KENBOX_2	0.0556
p.H956Q	ACH-000957	Colon/Colorectal Cancer	CCLE	DKENS	DEG_APCC_KENBOX_2	0.0556
p.H956Q	LS-180	large_intestine	COSMIC	DKENS	DEG_APCC_KENBOX_2	0.0556
p.T964A	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	DKENS	DEG_APCC_KENBOX_2	0.7222
p.T964A	ACH-000893	Lung Cancer	CCLE	DKENS	DEG_APCC_KENBOX_2	0.7222
p.T964A	NCI-H1651	lung	COSMIC	DKENS	DEG_APCC_KENBOX_2	0.7222
p.N969D	SIDM00875	Breast Carcinoma	GDSC	DKENS	DEG_APCC_KENBOX_2	0.6932
p.A975P	SIDM01372	Pancreatic Carcinoma	GDSC	DKENS	DEG_APCC_KENBOX_2	0.1944
p.A975P	ACH-000266	Pancreatic Cancer	CCLE	DKENS	DEG_APCC_KENBOX_2	0.1944
p.Q958K	ACH-001857	Bile Duct Cancer	CCLE	DKENS	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	DEG_APCC_KENBOX_2	509:513	DKENS	APC,CDC20,FZR1	0.5073	More...
Q5UIP0	Telomere-associated protein RIF1	DEG_APCC_KENBOX_2	1433:1437	DKENS	APC,CDC20,FZR1	0.9624	More...
Q9UIG0	Tyrosine-protein kinase BAZ1B	DEG_APCC_KENBOX_2	162:166	DKENS	APC,CDC20,FZR1	0.9945	More...
Q7RTY8	Transmembrane protease serine 7	DEG_APCC_KENBOX_2	2:6	DKENS	APC,CDC20,FZR1	0.6245	More...
Q5JPF3	Ankyrin repeat domain-containing protein 36C	DEG_APCC_KENBOX_2	966:970	DKENS	APC,CDC20,FZR1	0.998	More...
Q8N323	NXPE family member 1	DEG_APCC_KENBOX_2	270:274	DKENS	APC,CDC20,FZR1	0.9694	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons