DegronMD

Uniprot ID: Q5UIP0

Source protein: Telomere-associated protein RIF1

Source gene: RIF1

Class: DEG_APCC_KENBOX_2

Location: 1384:1388

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9973

ASA_SCORE: 119.54

COIL: 0.952

CONS_SCORE: 0.309

DSS_SCORE: 0.4796

HELIX: 0.0284

FCONS_SCORE: 1.1721

RIG_SCORE: 0.7042

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N1387D	TCGA-23-1021	OV	TCGA	SKENT	DEG_APCC_KENBOX_2	0.6932
p.N1387D	DO32183	OV	ICGC	SKENT	DEG_APCC_KENBOX_2	0.6932
p.N1387T	TCGA-A3-3317	KIRC	TCGA	SKENT	DEG_APCC_KENBOX_2	0.7055
p.K1376N	TCGA-HE-A5NH	KIRP	TCGA	SKENT	DEG_APCC_KENBOX_2	0.2222
p.K1376N	DO44485	KIRP	ICGC	SKENT	DEG_APCC_KENBOX_2	0.2222
p.S1384Y	TCGA-NJ-A4YP	LUAD	TCGA	SKENT	DEG_APCC_KENBOX_2	0.712
p.S1384Y	DO218943	LUAD	ICGC	SKENT	DEG_APCC_KENBOX_2	0.712
p.K1385Q	DO233629	GACA	ICGC	SKENT	DEG_APCC_KENBOX_2	0.6944
p.N1381K	SIDM02040	Esophageal Carcinoma	GDSC	SKENT	DEG_APCC_KENBOX_2	0.25
p.S1394P	SIDM00589	Oral Cavity Carcinoma	GDSC	SKENT	DEG_APCC_KENBOX_2	0.6111
p.S1394P	SIDM01756	Chronic Myelogenous Leukemia	GDSC	SKENT	DEG_APCC_KENBOX_2	0.6111
p.S1394P	ACH-000076	Leukemia	CCLE	SKENT	DEG_APCC_KENBOX_2	0.6111
p.S1394P	ACH-000778	Head and Neck Cancer	CCLE	SKENT	DEG_APCC_KENBOX_2	0.6111
p.S1394P	HSC-3	upper_aerodigestive_tract	COSMIC	SKENT	DEG_APCC_KENBOX_2	0.6111
p.E1386D	SIDM01588	Endometrial Carcinoma	GDSC	SKENT	DEG_APCC_KENBOX_2	0.6758
p.E1386D	ACH-000993	Endometrial/Uterine Cancer	CCLE	SKENT	DEG_APCC_KENBOX_2	0.6758
p.P1390T	ACH-000954	Endometrial/Uterine Cancer	CCLE	SKENT	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60861	Growth arrest-specific protein 7	DEG_APCC_KENBOX_2	169:173	SKENT	APC,CDC20,FZR1	0.8832	More...
P56715	Oxygen-regulated protein 1	DEG_APCC_KENBOX_2	1347:1351	SKENT	APC,CDC20,FZR1	0.9775	More...
Q5UIP0	Telomere-associated protein RIF1	DEG_APCC_KENBOX_2	1384:1388	SKENT	APC,CDC20,FZR1	0.9973	More...
Q5UIP0	Telomere-associated protein RIF1	DEG_APCC_KENBOX_2	1818:1822	SKENT	APC,CDC20,FZR1	0.9945	More...
Q7Z5K2	Wings apart-like protein homolog	DEG_APCC_KENBOX_2	535:539	SKENT	APC,CDC20,FZR1	0.9938	More...
Q9NXR8	Inhibitor of growth protein 3	DEG_APCC_KENBOX_2	180:184	SKENT	APC,CDC20,FZR1	0.8218	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons