DegronMD

Uniprot ID: O60861

Source protein: Growth arrest-specific protein 7

Source gene: GAS7

Class: DEG_APCC_KENBOX_2

Location: 169:173

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8832

ASA_SCORE: 96.18

COIL: 0.7942

CONS_SCORE: 0.3311

DSS_SCORE: 0.5194

HELIX: 0.083

FCONS_SCORE: 0.8278

RIG_SCORE: 0.6414

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G160E	TCGA-77-7142	LUSC	TCGA	SKENT	DEG_APCC_KENBOX_2	0.0833
p.G160R	TCGA-BF-AAP7	SKCM	TCGA	SKENT	DEG_APCC_KENBOX_2	0.0833
p.S163P	TCGA-BG-A222	UCEC	TCGA	SKENT	DEG_APCC_KENBOX_2	0.6111
p.T180M	TCGA-CD-A4MG	STAD	TCGA	SKENT	DEG_APCC_KENBOX_2	0.1389
p.S165N	TCGA-QF-A5YS	UCEC	TCGA	SKENT	DEG_APCC_KENBOX_2	0.6667
p.R178Q	DO233767	GACA	ICGC	SKENT	DEG_APCC_KENBOX_2	0.1944
p.R178Q	DO41422	UCEC	ICGC	SKENT	DEG_APCC_KENBOX_2	0.1944
p.Q163K	DO229028	LICA	ICGC	SKENT	DEG_APCC_KENBOX_2	0.6111
p.R178W	DO38727	STAD	ICGC	SKENT	DEG_APCC_KENBOX_2	0.1944
p.K182T	DO43907	UCEC	ICGC	SKENT	DEG_APCC_KENBOX_2	0.0833
p.K170T	SIDM00111	Glioma	GDSC	SKENT	DEG_APCC_KENBOX_2	0.7306
p.K170T	ACH-000232	Brain Cancer	CCLE	SKENT	DEG_APCC_KENBOX_2	0.7306
p.K170T	U251	central_nervous_system	COSMIC	SKENT	DEG_APCC_KENBOX_2	0.7306
p.S163L	SIDM01146	Gastric Carcinoma	GDSC	SKENT	DEG_APCC_KENBOX_2	0.6111
p.S163L	ACH-000932	Gastric Cancer	CCLE	SKENT	DEG_APCC_KENBOX_2	0.6111
p.S163L	NCI-SNU-1	stomach	COSMIC	SKENT	DEG_APCC_KENBOX_2	0.6111
p.I182V	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	SKENT	DEG_APCC_KENBOX_2	0.0833
p.D161Y	TE-4	oesophagus	COSMIC	SKENT	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60861	Growth arrest-specific protein 7	DEG_APCC_KENBOX_2	169:173	SKENT	APC,CDC20,FZR1	0.8832	More...
P56715	Oxygen-regulated protein 1	DEG_APCC_KENBOX_2	1347:1351	SKENT	APC,CDC20,FZR1	0.9775	More...
Q5UIP0	Telomere-associated protein RIF1	DEG_APCC_KENBOX_2	1384:1388	SKENT	APC,CDC20,FZR1	0.9973	More...
Q5UIP0	Telomere-associated protein RIF1	DEG_APCC_KENBOX_2	1818:1822	SKENT	APC,CDC20,FZR1	0.9945	More...
Q7Z5K2	Wings apart-like protein homolog	DEG_APCC_KENBOX_2	535:539	SKENT	APC,CDC20,FZR1	0.9938	More...
Q9NXR8	Inhibitor of growth protein 3	DEG_APCC_KENBOX_2	180:184	SKENT	APC,CDC20,FZR1	0.8218	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons