DegronMD - O60861(GAS7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G160E	TCGA-77-7142	LUSC	TCGA	SKENT	DEG_APCC_KENBOX_2	169:173	Mutation rewiring degron network	0.0833
p.G160R	TCGA-BF-AAP7	SKCM	TCGA	SKENT	DEG_APCC_KENBOX_2	169:173	Mutation rewiring degron network	0.0833
p.S163P	TCGA-BG-A222	UCEC	TCGA	SKENT	DEG_APCC_KENBOX_2	169:173	Mutation blocking phosphorylation signal	0.6111
p.T180M	TCGA-CD-A4MG	STAD	TCGA	SKENT	DEG_APCC_KENBOX_2	169:173	Mutation rewiring degron network	0.1389
p.S88L	TCGA-CG-5723	STAD	TCGA	VNTTT	DEG_SPOP_SBC_1	96:100	Mutation blocking phosphorylation signal	0.5556
p.S88L	TCGA-S4-A8RP	PAAD	TCGA	VNTTT	DEG_SPOP_SBC_1	96:100	Mutation blocking phosphorylation signal	0.5556
p.G91V	TCGA-EY-A215	UCEC	TCGA	VNTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.1944
p.W105C	TCGA-F4-6460	COAD	TCGA	VNTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.1944
p.S165N	TCGA-QF-A5YS	UCEC	TCGA	SKENT	DEG_APCC_KENBOX_2	169:173	Mutation blocking phosphorylation signal	0.6667
p.S97F	DO52713	CLLE	ICGC	VNTTT	DEG_SPOP_SBC_1	96:100	Mutation altering degron motif	0.7982
p.S98P	DO234265	ESAD	ICGC	VNTTT	DEG_SPOP_SBC_1	96:100	Mutation altering degron motif	0.6752
p.R178Q	DO233767	GACA	ICGC	SKENT	DEG_APCC_KENBOX_2	169:173	Mutation rewiring degron network	0.1944
p.R178Q	DO41422	UCEC	ICGC	SKENT	DEG_APCC_KENBOX_2	169:173	Mutation rewiring degron network	0.1944
p.G90S	DO18184	KIRC	ICGC	VNTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.1667
p.G90S	DO49430	PACA	ICGC	VNTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.1667
p.Q163K	DO229028	LICA	ICGC	SKENT	DEG_APCC_KENBOX_2	169:173	Mutation blocking phosphorylation signal	0.6111
p.T109A	DO45261	LIRI	ICGC	VNTTT	DEG_SPOP_SBC_1	96:100	Mutation blocking phosphorylation signal	0.5278
p.G96E	DO26462	LUSC	ICGC	VNTTT	DEG_SPOP_SBC_1	96:100	Mutation altering degron motif	0.7199
p.G96R	DO219472	SKCM	ICGC	VNTTT	DEG_SPOP_SBC_1	96:100	Mutation altering degron motif	0.7568
p.R178W	DO38727	STAD	ICGC	SKENT	DEG_APCC_KENBOX_2	169:173	Mutation rewiring degron network	0.1944
p.S101N	DO52426	UCEC	ICGC	VNTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.3056
p.K182T	DO43907	UCEC	ICGC	SKENT	DEG_APCC_KENBOX_2	169:173	Mutation rewiring degron network	0.0833
p.K170T	SIDM00111	Glioma	GDSC	SKENT	DEG_APCC_KENBOX_2	169:173	Mutation altering degron motif	0.7306
p.K170T	ACH-000232	Brain Cancer	CCLE	SKENT	DEG_APCC_KENBOX_2	169:173	Mutation altering degron motif	0.7306
p.K170T	U251	central nervous system	COSMIC	SKENT	DEG_APCC_KENBOX_2	169:173	Mutation altering degron motif	0.7306
p.R107C	SIDM00493	Other Solid Cancers	GDSC	VNTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.1389
p.R107C	SIDM00431	T-Lymphoblastic Leukemia	GDSC	VNTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.1389
p.R107C	SIDM00220	Ovarian Carcinoma	GDSC	VNTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.1389
p.S163L	SIDM01146	Gastric Carcinoma	GDSC	SKENT	DEG_APCC_KENBOX_2	169:173	Mutation blocking phosphorylation signal	0.6111
p.S163L	ACH-000932	Gastric Cancer	CCLE	SKENT	DEG_APCC_KENBOX_2	169:173	Mutation blocking phosphorylation signal	0.6111
p.S163L	NCI-SNU-1	stomach	COSMIC	SKENT	DEG_APCC_KENBOX_2	169:173	Mutation blocking phosphorylation signal	0.6111
p.P89S	ACH-001132	Lymphoma	CCLE	VNTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.1389
p.K110T	U251	central nervous system	COSMIC	VNTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.0556
p.S99L	NCI-SNU-1	stomach	COSMIC	VNTTT	DEG_SPOP_SBC_1	96:100	Mutation altering degron motif	0.7667
p.S103L	NCI-SNU-1	stomach	COSMIC	VNTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.25
p.K106T	U251	central nervous system	COSMIC	VNTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.1667
p.I182V	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	SKENT	DEG_APCC_KENBOX_2	169:173	Mutation rewiring degron network	0.0833
p.D161Y	TE-4	oesophagus	COSMIC	SKENT	DEG_APCC_KENBOX_2	169:173	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GAS7

UniProt ID: O60861

Entrez ID: 8522

Protein name: Growth arrest-specific protein 7 (GAS-7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GAS7 in