DegronMD

Uniprot ID: O60861

Source protein: Growth arrest-specific protein 7

Source gene: GAS7

Class: DEG_SPOP_SBC_1

Location: 96:100

E3 ligase: SPOP

DEGRON score: 0.5222

ASA_SCORE: 44.86

COIL: 0.5042

CONS_SCORE: 0.4702

DSS_SCORE: 0.5385

HELIX: 0.059

FCONS_SCORE: 1.0859

RIG_SCORE: 0.7487

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S88L	TCGA-CG-5723	STAD	TCGA	VNTTT	DEG_SPOP_SBC_1	0.5556
p.S88L	TCGA-S4-A8RP	PAAD	TCGA	VNTTT	DEG_SPOP_SBC_1	0.5556
p.G91V	TCGA-EY-A215	UCEC	TCGA	VNTTT	DEG_SPOP_SBC_1	0.1944
p.W105C	TCGA-F4-6460	COAD	TCGA	VNTTT	DEG_SPOP_SBC_1	0.1944
p.S97F	DO52713	CLLE	ICGC	VNTTT	DEG_SPOP_SBC_1	0.7982
p.S98P	DO234265	ESAD	ICGC	VNTTT	DEG_SPOP_SBC_1	0.6752
p.G90S	DO18184	KIRC	ICGC	VNTTT	DEG_SPOP_SBC_1	0.1667
p.G90S	DO49430	PACA	ICGC	VNTTT	DEG_SPOP_SBC_1	0.1667
p.T109A	DO45261	LIRI	ICGC	VNTTT	DEG_SPOP_SBC_1	0.5278
p.G96E	DO26462	LUSC	ICGC	VNTTT	DEG_SPOP_SBC_1	0.7199
p.G96R	DO219472	SKCM	ICGC	VNTTT	DEG_SPOP_SBC_1	0.7568
p.S101N	DO52426	UCEC	ICGC	VNTTT	DEG_SPOP_SBC_1	0.3056
p.R107C	SIDM00493	Other Solid Cancers	GDSC	VNTTT	DEG_SPOP_SBC_1	0.1389
p.R107C	SIDM00431	T-Lymphoblastic Leukemia	GDSC	VNTTT	DEG_SPOP_SBC_1	0.1389
p.R107C	SIDM00220	Ovarian Carcinoma	GDSC	VNTTT	DEG_SPOP_SBC_1	0.1389
p.P89S	ACH-001132	Lymphoma	CCLE	VNTTT	DEG_SPOP_SBC_1	0.1389
p.K110T	U251	central_nervous_system	COSMIC	VNTTT	DEG_SPOP_SBC_1	0.0556
p.S99L	NCI-SNU-1	stomach	COSMIC	VNTTT	DEG_SPOP_SBC_1	0.7667
p.S103L	NCI-SNU-1	stomach	COSMIC	VNTTT	DEG_SPOP_SBC_1	0.25
p.K106T	U251	central_nervous_system	COSMIC	VNTTT	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60861	Growth arrest-specific protein 7	DEG_SPOP_SBC_1	96:100	VNTTT	SPOP	0.5222	More...
O60934	Nibrin	DEG_SPOP_SBC_1	358:362	VNTTT	SPOP	0.9805	More...
Q9HAZ2	Histone-lysine N-methyltransferase PRDM16	DEG_SPOP_SBC_1	607:611	VNTTT	SPOP	0.9305	More...
Q9H6D8	Fibronectin type III domain-containing protein 4	DEG_SPOP_SBC_1	96:100	VNTTT	SPOP	0.7213	More...
Q3C1V0	Membrane-spanning 4-domains subfamily A member 18	DEG_SPOP_SBC_1	335:339	VNTTT	SPOP	0.9964	More...
Q3C1V0	Membrane-spanning 4-domains subfamily A member 18	DEG_SPOP_SBC_1	342:346	VNTTT	SPOP	0.9552	More...
Q3C1V0	Membrane-spanning 4-domains subfamily A member 18	DEG_SPOP_SBC_1	370:374	VNTTT	SPOP	0.856	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons