DegronMD

Uniprot ID: O60934

Source protein: Nibrin

Source gene: NBN

Class: DEG_SPOP_SBC_1

Location: 358:362

E3 ligase: SPOP

DEGRON score: 0.9805

ASA_SCORE: 91.32

COIL: 0.872

CONS_SCORE: 0.2866

DSS_SCORE: 0.5611

HELIX: 0.0476

FCONS_SCORE: 0.7642

RIG_SCORE: 0.7413

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P354S	TCGA-AP-A051	UCEC	TCGA	VNTTT	DEG_SPOP_SBC_1	0.2222
p.T360I	TCGA-XK-AAIW	PRAD	TCGA	VNTTT	DEG_SPOP_SBC_1	0.7078
p.Q348R	DO50177	LGG	ICGC	VNTTT	DEG_SPOP_SBC_1	0.0556
p.Q369K	DO229022	LICA	ICGC	VNTTT	DEG_SPOP_SBC_1	0.1389
p.S372F	DO51276	SKCM	ICGC	VNTTT	DEG_SPOP_SBC_1	0.0556
p.P351S	DO42280	UCEC	ICGC	VNTTT	DEG_SPOP_SBC_1	0.25
p.S365Y	DO41584	UCEC	ICGC	VNTTT	DEG_SPOP_SBC_1	0.25
p.S365Y	DO41133	UCEC	ICGC	VNTTT	DEG_SPOP_SBC_1	0.25
p.S355N	SIDM02050	Colorectal Carcinoma	GDSC	VNTTT	DEG_SPOP_SBC_1	0.25
p.E350G	SIDM01156	Small Cell Lung Carcinoma	GDSC	VNTTT	DEG_SPOP_SBC_1	0.1111
p.E350G	ACH-000890	Lung Cancer	CCLE	VNTTT	DEG_SPOP_SBC_1	0.1111
p.E350G	SW1271	lung	COSMIC	VNTTT	DEG_SPOP_SBC_1	0.1111
p.A356T	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	VNTTT	DEG_SPOP_SBC_1	0.2778
p.A356T	ACH-000945	Lung Cancer	CCLE	VNTTT	DEG_SPOP_SBC_1	0.2778
p.A356T	NCI-H650	lung	COSMIC	VNTTT	DEG_SPOP_SBC_1	0.2778
p.Q366R	HCT-15	large_intestine	COSMIC	VNTTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60861	Growth arrest-specific protein 7	DEG_SPOP_SBC_1	96:100	VNTTT	SPOP	0.5222	More...
O60934	Nibrin	DEG_SPOP_SBC_1	358:362	VNTTT	SPOP	0.9805	More...
Q9HAZ2	Histone-lysine N-methyltransferase PRDM16	DEG_SPOP_SBC_1	607:611	VNTTT	SPOP	0.9305	More...
Q9H6D8	Fibronectin type III domain-containing protein 4	DEG_SPOP_SBC_1	96:100	VNTTT	SPOP	0.7213	More...
Q3C1V0	Membrane-spanning 4-domains subfamily A member 18	DEG_SPOP_SBC_1	335:339	VNTTT	SPOP	0.9964	More...
Q3C1V0	Membrane-spanning 4-domains subfamily A member 18	DEG_SPOP_SBC_1	342:346	VNTTT	SPOP	0.9552	More...
Q3C1V0	Membrane-spanning 4-domains subfamily A member 18	DEG_SPOP_SBC_1	370:374	VNTTT	SPOP	0.856	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons