DegronMD - Q9HAZ2(PRDM16)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G601C	TCGA-17-Z056	LUAD	TCGA	VNTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1667
p.D616Y	TCGA-86-8279	LUAD	TCGA	VNTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1944
p.T618A	TCGA-A6-6653	COAD	TCGA	VNTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1389
p.D597N	TCGA-BR-8487	STAD	TCGA	VNTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.0556
p.R820W	TCGA-EY-A1H0	UCEC	TCGA	KNHVYGE	LIG_APCC_ABBAyCdc20_2	824:830	Mutation rewiring degron network	0.2222
p.D614N	TCGA-FR-A7U9	SKCM	TCGA	VNTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.25
p.S597T	DO222404	BTCA	ICGC	VNTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.0556
p.T619A	DO10373	COAD	ICGC	VNTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1111
p.S600L	DO50346	ESAD	ICGC	VNTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1389
p.E838K	DO233088	GACA	ICGC	KNHVYGE	LIG_APCC_ABBAyCdc20_2	824:830	Mutation rewiring degron network	0.1111
p.V828F	DO229028	LICA	ICGC	KNHVYGE	LIG_APCC_ABBAyCdc20_2	824:830	Mutation altering degron motif	0.7068
p.D617Y	DO24140	LUAD	ICGC	VNTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1667
p.D615N	DO48546	SKCM	ICGC	VNTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.2222
p.D598N	DO47867	STAD	ICGC	VNTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.0833
p.R821W	DO43114	UCEC	ICGC	KNHVYGE	LIG_APCC_ABBAyCdc20_2	824:830	Mutation rewiring degron network	0.25
p.T621M	SIDM01960	Colorectal Carcinoma	GDSC	VNTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.0556
p.T621M	ACH-001111	Lymphoma	CCLE	VNTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.0556
p.G818S	SIDM00427	Ewing's Sarcoma	GDSC	KNHVYGE	LIG_APCC_ABBAyCdc20_2	824:830	Mutation rewiring degron network	0.1667
p.G818S	SIDM00678	Bladder Carcinoma	GDSC	KNHVYGE	LIG_APCC_ABBAyCdc20_2	824:830	Mutation rewiring degron network	0.1667
p.V607A	SIDM00188	Kidney Carcinoma	GDSC	VNTTT	DEG_SPOP_SBC_1	607:611	Mutation altering degron motif	0.5825
p.V607A	SIDM01711	Non-Cancerous	GDSC	VNTTT	DEG_SPOP_SBC_1	607:611	Mutation altering degron motif	0.5825
p.V607A	ACH-002350	Non-Cancerous	CCLE	VNTTT	DEG_SPOP_SBC_1	607:611	Mutation altering degron motif	0.5825
p.G817S	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	KNHVYGE	LIG_APCC_ABBAyCdc20_2	824:830	Mutation rewiring degron network	0.1389
p.A835T	ACH-000019	Breast Cancer	CCLE	KNHVYGE	LIG_APCC_ABBAyCdc20_2	824:830	Mutation rewiring degron network	0.1944
p.A835T	ACH-000028	Breast Cancer	CCLE	KNHVYGE	LIG_APCC_ABBAyCdc20_2	824:830	Mutation rewiring degron network	0.1944
p.H826R	ACH-001518	Endometrial/Uterine Cancer	CCLE	KNHVYGE	LIG_APCC_ABBAyCdc20_2	824:830	Mutation altering degron motif	0.7133

Kaplan plot for PRDM16 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRDM16

UniProt ID: Q9HAZ2

Entrez ID: 63976

Protein name: Histone-lysine N-methyltransferase PRDM16 (EC 2.1.1.367) (PR domain zinc finger protein 16) (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRDM16 in