DegronMD

Uniprot ID: Q9HAZ2

Source protein: Histone-lysine N-methyltransferase PRDM16

Source gene: PRDM16

Class: DEG_SPOP_SBC_1

Location: 607:611

E3 ligase: SPOP

DEGRON score: 0.9305

ASA_SCORE: 82.1

COIL: 0.801

CONS_SCORE: 0.4949

DSS_SCORE: 0.5364

HELIX: 0.0524

FCONS_SCORE: 1.0472

RIG_SCORE: 0.702

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G601C	TCGA-17-Z056	LUAD	TCGA	VNTTT	DEG_SPOP_SBC_1	0.1667
p.D616Y	TCGA-86-8279	LUAD	TCGA	VNTTT	DEG_SPOP_SBC_1	0.1944
p.T618A	TCGA-A6-6653	COAD	TCGA	VNTTT	DEG_SPOP_SBC_1	0.1389
p.D597N	TCGA-BR-8487	STAD	TCGA	VNTTT	DEG_SPOP_SBC_1	0.0556
p.D614N	TCGA-FR-A7U9	SKCM	TCGA	VNTTT	DEG_SPOP_SBC_1	0.25
p.S597T	DO222404	BTCA	ICGC	VNTTT	DEG_SPOP_SBC_1	0.0556
p.T619A	DO10373	COAD	ICGC	VNTTT	DEG_SPOP_SBC_1	0.1111
p.S600L	DO50346	ESAD	ICGC	VNTTT	DEG_SPOP_SBC_1	0.1389
p.D617Y	DO24140	LUAD	ICGC	VNTTT	DEG_SPOP_SBC_1	0.1667
p.D615N	DO48546	SKCM	ICGC	VNTTT	DEG_SPOP_SBC_1	0.2222
p.D598N	DO47867	STAD	ICGC	VNTTT	DEG_SPOP_SBC_1	0.0833
p.T621M	SIDM01960	Colorectal Carcinoma	GDSC	VNTTT	DEG_SPOP_SBC_1	0.0556
p.T621M	ACH-001111	Lymphoma	CCLE	VNTTT	DEG_SPOP_SBC_1	0.0556
p.V607A	SIDM00188	Kidney Carcinoma	GDSC	VNTTT	DEG_SPOP_SBC_1	0.5825
p.V607A	SIDM01711	Non-Cancerous	GDSC	VNTTT	DEG_SPOP_SBC_1	0.5825
p.V607A	ACH-002350	Non-Cancerous	CCLE	VNTTT	DEG_SPOP_SBC_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60861	Growth arrest-specific protein 7	DEG_SPOP_SBC_1	96:100	VNTTT	SPOP	0.5222	More...
O60934	Nibrin	DEG_SPOP_SBC_1	358:362	VNTTT	SPOP	0.9805	More...
Q9HAZ2	Histone-lysine N-methyltransferase PRDM16	DEG_SPOP_SBC_1	607:611	VNTTT	SPOP	0.9305	More...
Q9H6D8	Fibronectin type III domain-containing protein 4	DEG_SPOP_SBC_1	96:100	VNTTT	SPOP	0.7213	More...
Q3C1V0	Membrane-spanning 4-domains subfamily A member 18	DEG_SPOP_SBC_1	335:339	VNTTT	SPOP	0.9964	More...
Q3C1V0	Membrane-spanning 4-domains subfamily A member 18	DEG_SPOP_SBC_1	342:346	VNTTT	SPOP	0.9552	More...
Q3C1V0	Membrane-spanning 4-domains subfamily A member 18	DEG_SPOP_SBC_1	370:374	VNTTT	SPOP	0.856	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons