DegronMD - O60934(NBN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P354S	TCGA-AP-A051	UCEC	TCGA	VNTTT	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.2222
p.T360I	TCGA-XK-AAIW	PRAD	TCGA	VNTTT	DEG_SPOP_SBC_1	358:362	Mutation altering degron motif	0.7078
p.Q348R	DO50177	LGG	ICGC	VNTTT	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.0556
p.Q369K	DO229022	LICA	ICGC	VNTTT	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.1389
p.S372F	DO51276	SKCM	ICGC	VNTTT	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.0556
p.P351S	DO42280	UCEC	ICGC	VNTTT	DEG_SPOP_SBC_1	358:362	Mutation substituting flanking lysine	0.25
p.S365Y	DO41584	UCEC	ICGC	VNTTT	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.25
p.S365Y	DO41133	UCEC	ICGC	VNTTT	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.25
p.S355N	SIDM02050	Colorectal Carcinoma	GDSC	VNTTT	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.25
p.E350G	SIDM01156	Small Cell Lung Carcinoma	GDSC	VNTTT	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.1111
p.E350G	ACH-000890	Lung Cancer	CCLE	VNTTT	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.1111
p.E350G	SW1271	lung	COSMIC	VNTTT	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.1111
p.A356T	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	VNTTT	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.2778
p.A356T	ACH-000945	Lung Cancer	CCLE	VNTTT	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.2778
p.A356T	NCI-H650	lung	COSMIC	VNTTT	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.2778
p.Q366R	HCT-15	large intestine	COSMIC	VNTTT	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.2222

Kaplan plot for NBN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NBN

UniProt ID: O60934

Entrez ID: 4683

Protein name: Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NBN in