DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VNTTT
Uniprot ID:
Q3C1V0
Source protein:
Membrane-spanning 4-domains subfamily A member 18
Source gene:
MS4A18
Class:
DEG_SPOP_SBC_1
Location:
335:339
E3 ligase:
SPOP
DEGRON score:
0.9964
ASA_SCORE:
102.18
COIL:
0.9482
CONS_SCORE:
0
DSS_SCORE:
0.596
HELIX:
0.014
FCONS_SCORE:
0
RIG_SCORE:
0.727
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MS4A18 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VNTTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O60861
Growth arrest-specific protein 7
DEG_SPOP_SBC_1
96:100
VNTTT
SPOP
0.5222
More...
O60934
Nibrin
DEG_SPOP_SBC_1
358:362
VNTTT
SPOP
0.9805
More...
Q9HAZ2
Histone-lysine N-methyltransferase PRDM16
DEG_SPOP_SBC_1
607:611
VNTTT
SPOP
0.9305
More...
Q9H6D8
Fibronectin type III domain-containing protein 4
DEG_SPOP_SBC_1
96:100
VNTTT
SPOP
0.7213
More...
Q3C1V0
Membrane-spanning 4-domains subfamily A member 18
DEG_SPOP_SBC_1
335:339
VNTTT
SPOP
0.9964
More...
Q3C1V0
Membrane-spanning 4-domains subfamily A member 18
DEG_SPOP_SBC_1
342:346
VNTTT
SPOP
0.9552
More...
Q3C1V0
Membrane-spanning 4-domains subfamily A member 18
DEG_SPOP_SBC_1
370:374
VNTTT
SPOP
0.856
More...