DegronMD

Uniprot ID: Q9H6D8

Source protein: Fibronectin type III domain-containing protein 4

Source gene: FNDC4

Class: DEG_SPOP_SBC_1

Location: 96:100

E3 ligase: SPOP

DEGRON score: 0.7213

ASA_SCORE: 71.14

COIL: 0.707

CONS_SCORE: 0.9403

DSS_SCORE: 0.2748

HELIX: 0.0286

FCONS_SCORE: 1.0985

RIG_SCORE: 0.8551

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W106C	TCGA-CK-6746	COAD	TCGA	VNTTT	DEG_SPOP_SBC_1	0.1667
p.W106C	DO7938	COAD	ICGC	VNTTT	DEG_SPOP_SBC_1	0.1667
p.G89E	DO229257	THCA	ICGC	VNTTT	DEG_SPOP_SBC_1	0.1389
p.R91H	SIDM00990	Non-Small Cell Lung Carcinoma	GDSC	VNTTT	DEG_SPOP_SBC_1	0.1944
p.R91H	ACH-000603	Lung Cancer	CCLE	VNTTT	DEG_SPOP_SBC_1	0.1944
p.R91H	BEN	lung	COSMIC	VNTTT	DEG_SPOP_SBC_1	0.1944
p.R101P	SIDM00166	Other Solid Cancers	GDSC	VNTTT	DEG_SPOP_SBC_1	0.3056
p.R101P	ACH-000302	Endometrial/Uterine Cancer	CCLE	VNTTT	DEG_SPOP_SBC_1	0.3056
p.R94W	SIDM01619	Endometrial Carcinoma	GDSC	VNTTT	DEG_SPOP_SBC_1	0.2778
p.R94W	ACH-000984	Endometrial/Uterine Cancer	CCLE	VNTTT	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60861	Growth arrest-specific protein 7	DEG_SPOP_SBC_1	96:100	VNTTT	SPOP	0.5222	More...
O60934	Nibrin	DEG_SPOP_SBC_1	358:362	VNTTT	SPOP	0.9805	More...
Q9HAZ2	Histone-lysine N-methyltransferase PRDM16	DEG_SPOP_SBC_1	607:611	VNTTT	SPOP	0.9305	More...
Q9H6D8	Fibronectin type III domain-containing protein 4	DEG_SPOP_SBC_1	96:100	VNTTT	SPOP	0.7213	More...
Q3C1V0	Membrane-spanning 4-domains subfamily A member 18	DEG_SPOP_SBC_1	335:339	VNTTT	SPOP	0.9964	More...
Q3C1V0	Membrane-spanning 4-domains subfamily A member 18	DEG_SPOP_SBC_1	342:346	VNTTT	SPOP	0.9552	More...
Q3C1V0	Membrane-spanning 4-domains subfamily A member 18	DEG_SPOP_SBC_1	370:374	VNTTT	SPOP	0.856	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons