DegronMD - Q3C1V0(MS4A18)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N296K	DO229355	BTCA	ICGC	ANTTT	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.2222
p.T300A	DO227587	COCA	ICGC	ANTTT	DEG_SPOP_SBC_1	300:304	Mutation altering degron motif	0.7139
p.N58S	DO227709	COCA	ICGC	GRANLQNLL	DEG_APCC_DBOX_1	55:63	Mutation altering degron motif	0.5958
p.V64M	DO229480	LAML	ICGC	GRANLQNLL	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.3056
p.V64M	DO231072	LUSC	ICGC	GRANLQNLL	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.3056
p.V65L	DO27334	LUSC	ICGC	GRANLQNLL	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.2778
p.N306K	DO222542	MELA	ICGC	ANTTT	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.2778
p.G72D	ACH-000779	Lung Cancer	CCLE	GRANLQNLL	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.0833
p.I45V	ACH-001804	Liposarcoma	CCLE	GRANLQNLL	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.0556
p.R56G	ACH-001959	Bile Duct Cancer	CCLE	GRANLQNLL	DEG_APCC_DBOX_1	55:63	Mutation altering degron motif	0.7568

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons