DegronMD

Uniprot ID: Q3C1V0

Source protein: Membrane-spanning 4-domains subfamily A member 18

Source gene: MS4A18

Class: DEG_SPOP_SBC_1

Location: 300:304

E3 ligase: SPOP

DEGRON score: 0.9649

ASA_SCORE: 84.22

COIL: 0.907

CONS_SCORE: 0.7764

DSS_SCORE: 0.3504

HELIX: 0.0306

FCONS_SCORE: 1.3347

RIG_SCORE: 0.7229

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N296K	DO229355	BTCA	ICGC	ANTTT	DEG_SPOP_SBC_1	0.2222
p.T300A	DO227587	COCA	ICGC	ANTTT	DEG_SPOP_SBC_1	0.7139
p.N306K	DO222542	MELA	ICGC	ANTTT	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1848:1852	ANTTT	SPOP	0.9805	More...
Q2TV78	Putative macrophage stimulating 1-like protein	DEG_SPOP_SBC_1	265:269	ANTTT	SPOP	0.5321	More...
Q3C1V0	Membrane-spanning 4-domains subfamily A member 18	DEG_SPOP_SBC_1	300:304	ANTTT	SPOP	0.9649	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons