DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ANTTT
Uniprot ID:
Q2TV78
Source protein:
Putative macrophage stimulating 1-like protein
Source gene:
MST1L
Class:
DEG_SPOP_SBC_1
Location:
265:269
E3 ligase:
SPOP
DEGRON score:
0.5321
ASA_SCORE:
59.48
COIL:
0.61
CONS_SCORE:
0.5783
DSS_SCORE:
0.3991
HELIX:
0.0448
FCONS_SCORE:
1.2226
RIG_SCORE:
0.7615
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MST1L mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ANTTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q2M2H8
Probable maltase-glucoamylase 2
DEG_SPOP_SBC_1
1848:1852
ANTTT
SPOP
0.9805
More...
Q2TV78
Putative macrophage stimulating 1-like protein
DEG_SPOP_SBC_1
265:269
ANTTT
SPOP
0.5321
More...
Q3C1V0
Membrane-spanning 4-domains subfamily A member 18
DEG_SPOP_SBC_1
300:304
ANTTT
SPOP
0.9649
More...