DegronMD

Uniprot ID: Q3C1V0

Source protein: Membrane-spanning 4-domains subfamily A member 18

Source gene: MS4A18

Class: DEG_APCC_DBOX_1

Location: 55:63

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7851

ASA_SCORE: 81.6

COIL: 0.7758

CONS_SCORE: 0.7176

DSS_SCORE: 0.273

HELIX: 0.0988

FCONS_SCORE: 1.3296

RIG_SCORE: 0.8243

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N58S	DO227709	COCA	ICGC	GRANLQNLL	DEG_APCC_DBOX_1	0.5958
p.V64M	DO229480	LAML	ICGC	GRANLQNLL	DEG_APCC_DBOX_1	0.3056
p.V64M	DO231072	LUSC	ICGC	GRANLQNLL	DEG_APCC_DBOX_1	0.3056
p.V65L	DO27334	LUSC	ICGC	GRANLQNLL	DEG_APCC_DBOX_1	0.2778
p.G72D	ACH-000779	Lung Cancer	CCLE	GRANLQNLL	DEG_APCC_DBOX_1	0.0833
p.I45V	ACH-001804	Liposarcoma	CCLE	GRANLQNLL	DEG_APCC_DBOX_1	0.0556
p.R56G	ACH-001959	Bile Duct Cancer	CCLE	GRANLQNLL	DEG_APCC_DBOX_1	0.7568

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3C1V0	Membrane-spanning 4-domains subfamily A member 18	DEG_APCC_DBOX_1	55:63	GRANLQNLL	APC,CDC20,FZR1	0.7851	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons