DegronMD

Uniprot ID: Q9HAZ2

Source protein: Histone-lysine N-methyltransferase PRDM16

Source gene: PRDM16

Class: LIG_APCC_ABBAyCdc20_2

Location: 824:830

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.897

ASA_SCORE: 99.4857

COIL: 0.7326

CONS_SCORE: 0.4066

DSS_SCORE: 0.6572

HELIX: 0.0441

FCONS_SCORE: 1.4075

RIG_SCORE: 0.6824

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R820W	TCGA-EY-A1H0	UCEC	TCGA	KNHVYGE	LIG_APCC_ABBAyCdc20_2	0.2222
p.E838K	DO233088	GACA	ICGC	KNHVYGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.V828F	DO229028	LICA	ICGC	KNHVYGE	LIG_APCC_ABBAyCdc20_2	0.7068
p.R821W	DO43114	UCEC	ICGC	KNHVYGE	LIG_APCC_ABBAyCdc20_2	0.25
p.G818S	SIDM00427	Ewing's Sarcoma	GDSC	KNHVYGE	LIG_APCC_ABBAyCdc20_2	0.1667
p.G818S	SIDM00678	Bladder Carcinoma	GDSC	KNHVYGE	LIG_APCC_ABBAyCdc20_2	0.1667
p.G817S	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	KNHVYGE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A835T	ACH-000019	Breast Cancer	CCLE	KNHVYGE	LIG_APCC_ABBAyCdc20_2	0.1944
p.A835T	ACH-000028	Breast Cancer	CCLE	KNHVYGE	LIG_APCC_ABBAyCdc20_2	0.1944
p.H826R	ACH-001518	Endometrial/Uterine Cancer	CCLE	KNHVYGE	LIG_APCC_ABBAyCdc20_2	0.7133

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HAZ2	Histone-lysine N-methyltransferase PRDM16	LIG_APCC_ABBAyCdc20_2	824:830	KNHVYGE	APC,CDC20,FZR1	0.897	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons