DegronMD - Q9NXR8(ING3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T193A	TCGA-50-6594	LUAD	TCGA	SKENT	DEG_APCC_KENBOX_2	180:184	Mutation rewiring degron network	0.0833
p.T193A	DO24275	LUAD	ICGC	SKENT	DEG_APCC_KENBOX_2	180:184	Mutation rewiring degron network	0.0833
p.R188Q	TCGA-AA-A00N	COAD	TCGA	SKENT	DEG_APCC_KENBOX_2	180:184	Mutation rewiring degron network	0.2222
p.R188Q	TCGA-AZ-4315	COAD	TCGA	SKENT	DEG_APCC_KENBOX_2	180:184	Mutation rewiring degron network	0.2222
p.R188Q	TCGA-D8-A1J8	BRCA	TCGA	SKENT	DEG_APCC_KENBOX_2	180:184	Mutation rewiring degron network	0.2222
p.R188Q	TCGA-VQ-A8P2	STAD	TCGA	SKENT	DEG_APCC_KENBOX_2	180:184	Mutation rewiring degron network	0.2222
p.R188Q	DO1269	BRCA	ICGC	SKENT	DEG_APCC_KENBOX_2	180:184	Mutation rewiring degron network	0.2222
p.R188Q	DO8842	COAD	ICGC	SKENT	DEG_APCC_KENBOX_2	180:184	Mutation rewiring degron network	0.2222
p.R188Q	DO9876	COAD	ICGC	SKENT	DEG_APCC_KENBOX_2	180:184	Mutation rewiring degron network	0.2222
p.R188Q	DO51761	STAD	ICGC	SKENT	DEG_APCC_KENBOX_2	180:184	Mutation rewiring degron network	0.2222
p.K181T	TCGA-CA-6718	COAD	TCGA	SKENT	DEG_APCC_KENBOX_2	180:184	Mutation altering degron motif	0.7306
p.K181T	DO7801	COAD	ICGC	SKENT	DEG_APCC_KENBOX_2	180:184	Mutation altering degron motif	0.7306
p.Q191K	Raji	haematopoietic and lymphoid tissue	COSMIC	SKENT	DEG_APCC_KENBOX_2	180:184	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons