DegronMD

Uniprot ID: Q9NXR8

Source protein: Inhibitor of growth protein 3

Source gene: ING3

Class: DEG_APCC_KENBOX_2

Location: 180:184

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8218

ASA_SCORE: 85.42

COIL: 0.7094

CONS_SCORE: 0.364

DSS_SCORE: 0.4947

HELIX: 0.2176

FCONS_SCORE: 0.9165

RIG_SCORE: 0.711

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T193A	TCGA-50-6594	LUAD	TCGA	SKENT	DEG_APCC_KENBOX_2	0.0833
p.T193A	DO24275	LUAD	ICGC	SKENT	DEG_APCC_KENBOX_2	0.0833
p.R188Q	TCGA-AA-A00N	COAD	TCGA	SKENT	DEG_APCC_KENBOX_2	0.2222
p.R188Q	TCGA-AZ-4315	COAD	TCGA	SKENT	DEG_APCC_KENBOX_2	0.2222
p.R188Q	TCGA-D8-A1J8	BRCA	TCGA	SKENT	DEG_APCC_KENBOX_2	0.2222
p.R188Q	TCGA-VQ-A8P2	STAD	TCGA	SKENT	DEG_APCC_KENBOX_2	0.2222
p.R188Q	DO1269	BRCA	ICGC	SKENT	DEG_APCC_KENBOX_2	0.2222
p.R188Q	DO8842	COAD	ICGC	SKENT	DEG_APCC_KENBOX_2	0.2222
p.R188Q	DO9876	COAD	ICGC	SKENT	DEG_APCC_KENBOX_2	0.2222
p.R188Q	DO51761	STAD	ICGC	SKENT	DEG_APCC_KENBOX_2	0.2222
p.K181T	TCGA-CA-6718	COAD	TCGA	SKENT	DEG_APCC_KENBOX_2	0.7306
p.K181T	DO7801	COAD	ICGC	SKENT	DEG_APCC_KENBOX_2	0.7306
p.Q191K	Raji	haematopoietic_and_lymphoid_tissue	COSMIC	SKENT	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60861	Growth arrest-specific protein 7	DEG_APCC_KENBOX_2	169:173	SKENT	APC,CDC20,FZR1	0.8832	More...
P56715	Oxygen-regulated protein 1	DEG_APCC_KENBOX_2	1347:1351	SKENT	APC,CDC20,FZR1	0.9775	More...
Q5UIP0	Telomere-associated protein RIF1	DEG_APCC_KENBOX_2	1384:1388	SKENT	APC,CDC20,FZR1	0.9973	More...
Q5UIP0	Telomere-associated protein RIF1	DEG_APCC_KENBOX_2	1818:1822	SKENT	APC,CDC20,FZR1	0.9945	More...
Q7Z5K2	Wings apart-like protein homolog	DEG_APCC_KENBOX_2	535:539	SKENT	APC,CDC20,FZR1	0.9938	More...
Q9NXR8	Inhibitor of growth protein 3	DEG_APCC_KENBOX_2	180:184	SKENT	APC,CDC20,FZR1	0.8218	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons