DegronMD

Uniprot ID: Q5UIP0

Source protein: Telomere-associated protein RIF1

Source gene: RIF1

Class: DEG_APCC_KENBOX_2

Location: 1818:1822

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9945

ASA_SCORE: 105.78

COIL: 0.7754

CONS_SCORE: 0.2687

DSS_SCORE: 0.537

HELIX: 0.1966

FCONS_SCORE: 1.0504

RIG_SCORE: 0.7078

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1814F	TCGA-AG-3892	READ	TCGA	SKENT	DEG_APCC_KENBOX_2	0.2222
p.S1814F	DO36394	READ	ICGC	SKENT	DEG_APCC_KENBOX_2	0.2222
p.S1826Y	TCGA-BS-A0TC	UCEC	TCGA	SKENT	DEG_APCC_KENBOX_2	0.6667
p.S1826Y	DO42400	UCEC	ICGC	SKENT	DEG_APCC_KENBOX_2	0.6667
p.V1832A	TCGA-DI-A1BU	UCEC	TCGA	SKENT	DEG_APCC_KENBOX_2	0.0556
p.V1832A	DO42023	UCEC	ICGC	SKENT	DEG_APCC_KENBOX_2	0.0556
p.S1810L	TCGA-FD-A3B3	BLCA	TCGA	SKENT	DEG_APCC_KENBOX_2	0.5556
p.S1810L	DO749	BLCA	ICGC	SKENT	DEG_APCC_KENBOX_2	0.5556
p.S1818L	TCGA-GN-A26C	SKCM	TCGA	SKENT	DEG_APCC_KENBOX_2	0.7667
p.S1818L	DO233733	GACA	ICGC	SKENT	DEG_APCC_KENBOX_2	0.7667
p.S1818L	DO37782	SKCM	ICGC	SKENT	DEG_APCC_KENBOX_2	0.7667
p.K1819R	TCGA-UY-A78K	BLCA	TCGA	SKENT	DEG_APCC_KENBOX_2	0.7237
p.K1819R	DO219031	BLCA	ICGC	SKENT	DEG_APCC_KENBOX_2	0.7237
p.K1819R	DO231772	LINC	ICGC	SKENT	DEG_APCC_KENBOX_2	0.7237
p.T1816I	DO233245	GACA	ICGC	SKENT	DEG_APCC_KENBOX_2	0.2778
p.V1813F	DO229028	LICA	ICGC	SKENT	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60861	Growth arrest-specific protein 7	DEG_APCC_KENBOX_2	169:173	SKENT	APC,CDC20,FZR1	0.8832	More...
P56715	Oxygen-regulated protein 1	DEG_APCC_KENBOX_2	1347:1351	SKENT	APC,CDC20,FZR1	0.9775	More...
Q5UIP0	Telomere-associated protein RIF1	DEG_APCC_KENBOX_2	1384:1388	SKENT	APC,CDC20,FZR1	0.9973	More...
Q5UIP0	Telomere-associated protein RIF1	DEG_APCC_KENBOX_2	1818:1822	SKENT	APC,CDC20,FZR1	0.9945	More...
Q7Z5K2	Wings apart-like protein homolog	DEG_APCC_KENBOX_2	535:539	SKENT	APC,CDC20,FZR1	0.9938	More...
Q9NXR8	Inhibitor of growth protein 3	DEG_APCC_KENBOX_2	180:184	SKENT	APC,CDC20,FZR1	0.8218	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons