DegronMD

Uniprot ID: Q7Z5K2

Source protein: Wings apart-like protein homolog

Source gene: WAPL

Class: DEG_APCC_KENBOX_2

Location: 535:539

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9938

ASA_SCORE: 96.9

COIL: 0.8132

CONS_SCORE: 0.3452

DSS_SCORE: 0.6778

HELIX: 0.1484

FCONS_SCORE: 1.0096

RIG_SCORE: 0.6838

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S549A	SIDM01293	Colorectal Carcinoma	GDSC	SKENT	DEG_APCC_KENBOX_2	0.5
p.N529S	SIDM00845	Burkitt's Lymphoma	GDSC	SKENT	DEG_APCC_KENBOX_2	0.1667
p.N529S	SIDM00461	Acute Myeloid Leukemia	GDSC	SKENT	DEG_APCC_KENBOX_2	0.1667
p.N529S	SIDM01519	Head and Neck Carcinoma	GDSC	SKENT	DEG_APCC_KENBOX_2	0.1667
p.N529S	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	SKENT	DEG_APCC_KENBOX_2	0.1667
p.N538S	SIDM01611	Endometrial Carcinoma	GDSC	SKENT	DEG_APCC_KENBOX_2	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60861	Growth arrest-specific protein 7	DEG_APCC_KENBOX_2	169:173	SKENT	APC,CDC20,FZR1	0.8832	More...
P56715	Oxygen-regulated protein 1	DEG_APCC_KENBOX_2	1347:1351	SKENT	APC,CDC20,FZR1	0.9775	More...
Q5UIP0	Telomere-associated protein RIF1	DEG_APCC_KENBOX_2	1384:1388	SKENT	APC,CDC20,FZR1	0.9973	More...
Q5UIP0	Telomere-associated protein RIF1	DEG_APCC_KENBOX_2	1818:1822	SKENT	APC,CDC20,FZR1	0.9945	More...
Q7Z5K2	Wings apart-like protein homolog	DEG_APCC_KENBOX_2	535:539	SKENT	APC,CDC20,FZR1	0.9938	More...
Q9NXR8	Inhibitor of growth protein 3	DEG_APCC_KENBOX_2	180:184	SKENT	APC,CDC20,FZR1	0.8218	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons