DegronMD

Uniprot ID: P56715

Source protein: Oxygen-regulated protein 1

Source gene: RP1

Class: DEG_APCC_KENBOX_2

Location: 1347:1351

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9775

ASA_SCORE: 114.04

COIL: 0.8204

CONS_SCORE: 0.3273

DSS_SCORE: 0.3469

HELIX: 0.1472

FCONS_SCORE: 0.8737

RIG_SCORE: 0.7759

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1354N	TCGA-21-1079	LUSC	TCGA	SKENT	DEG_APCC_KENBOX_2	0.25
p.D1354N	DO228126	EOPC	ICGC	SKENT	DEG_APCC_KENBOX_2	0.25
p.D1354N	DO26846	LUSC	ICGC	SKENT	DEG_APCC_KENBOX_2	0.25
p.V1338A	TCGA-33-4532	LUSC	TCGA	SKENT	DEG_APCC_KENBOX_2	0.0833
p.V1338A	DO26626	LUSC	ICGC	SKENT	DEG_APCC_KENBOX_2	0.0833
p.L1345F	TCGA-44-8120	LUAD	TCGA	SKENT	DEG_APCC_KENBOX_2	0.2778
p.L1345F	TCGA-QB-AA9O	SKCM	TCGA	SKENT	DEG_APCC_KENBOX_2	0.2778
p.L1345F	DO45402	LUAD	ICGC	SKENT	DEG_APCC_KENBOX_2	0.2778
p.L1345F	DO51267	SKCM	ICGC	SKENT	DEG_APCC_KENBOX_2	0.2778
p.T1359S	TCGA-50-5066	LUAD	TCGA	SKENT	DEG_APCC_KENBOX_2	0.1111
p.T1359S	DO25040	LUAD	ICGC	SKENT	DEG_APCC_KENBOX_2	0.1111
p.D1343N	TCGA-AN-A041	BRCA	TCGA	SKENT	DEG_APCC_KENBOX_2	0.2222
p.D1343N	DO5625	BRCA	ICGC	SKENT	DEG_APCC_KENBOX_2	0.2222
p.D1357Y	TCGA-AX-A2HC	UCEC	TCGA	SKENT	DEG_APCC_KENBOX_2	0.1667
p.D1357Y	DO41572	UCEC	ICGC	SKENT	DEG_APCC_KENBOX_2	0.1667
p.T1353I	TCGA-D3-A3ML	SKCM	TCGA	SKENT	DEG_APCC_KENBOX_2	0.2778
p.T1353I	DO47413	SKCM	ICGC	SKENT	DEG_APCC_KENBOX_2	0.2778
p.S1347F	TCGA-DA-A95Z	SKCM	TCGA	SKENT	DEG_APCC_KENBOX_2	0.6871
p.S1347F	TCGA-E2-A574	BRCA	TCGA	SKENT	DEG_APCC_KENBOX_2	0.6871
p.S1347F	DO49022	BRCA	ICGC	SKENT	DEG_APCC_KENBOX_2	0.6871
p.S1347F	DO219481	SKCM	ICGC	SKENT	DEG_APCC_KENBOX_2	0.6871
p.E1349K	TCGA-EB-A3Y7	SKCM	TCGA	SKENT	DEG_APCC_KENBOX_2	0.7022
p.E1349K	DO229456	SKCA	ICGC	SKENT	DEG_APCC_KENBOX_2	0.7022
p.E1349K	DO37499	SKCM	ICGC	SKENT	DEG_APCC_KENBOX_2	0.7022
p.D1357E	TCGA-EE-A20C	SKCM	TCGA	SKENT	DEG_APCC_KENBOX_2	0.1667
p.D1357E	DO222775	MELA	ICGC	SKENT	DEG_APCC_KENBOX_2	0.1667
p.D1357E	DO47665	SKCM	ICGC	SKENT	DEG_APCC_KENBOX_2	0.1667
p.E1360K	TCGA-EE-A2MD	SKCM	TCGA	SKENT	DEG_APCC_KENBOX_2	0.0833
p.E1360K	DO222434	MELA	ICGC	SKENT	DEG_APCC_KENBOX_2	0.0833
p.E1360K	DO37851	SKCM	ICGC	SKENT	DEG_APCC_KENBOX_2	0.0833
p.E1360K	SIDM01059	Melanoma	GDSC	SKENT	DEG_APCC_KENBOX_2	0.0833
p.E1360K	ACH-000915	Skin Cancer	CCLE	SKENT	DEG_APCC_KENBOX_2	0.0833
p.E1360K	IPC-298	skin	COSMIC	SKENT	DEG_APCC_KENBOX_2	0.0833
p.L1345I	TCGA-EE-A2MR	SKCM	TCGA	SKENT	DEG_APCC_KENBOX_2	0.2778
p.L1345I	DO37819	SKCM	ICGC	SKENT	DEG_APCC_KENBOX_2	0.2778
p.D1357N	TCGA-GN-A269	SKCM	TCGA	SKENT	DEG_APCC_KENBOX_2	0.1667
p.D1357N	DO37483	SKCM	ICGC	SKENT	DEG_APCC_KENBOX_2	0.1667
p.C1339F	TCGA-KQ-A41Q	BLCA	TCGA	SKENT	DEG_APCC_KENBOX_2	0.1111
p.C1339F	DO223591	BLCA	ICGC	SKENT	DEG_APCC_KENBOX_2	0.1111
p.E1349G	DO48314	ESCA	ICGC	SKENT	DEG_APCC_KENBOX_2	0.7199
p.K1348N	DO233689	GACA	ICGC	SKENT	DEG_APCC_KENBOX_2	0.6918
p.V1338F	DO229034	LICA	ICGC	SKENT	DEG_APCC_KENBOX_2	0.0833
p.T1341I	DO222710	MELA	ICGC	SKENT	DEG_APCC_KENBOX_2	0.1667
p.I1349T	SIDM02074	Esophageal Carcinoma	GDSC	SKENT	DEG_APCC_KENBOX_2	0.7078
p.F1344L	SIDM00967	Ovarian Carcinoma	GDSC	SKENT	DEG_APCC_KENBOX_2	0.25
p.F1344L	SIDM00844	Burkitt's Lymphoma	GDSC	SKENT	DEG_APCC_KENBOX_2	0.25
p.S1358L	SIDM00562	Breast Carcinoma	GDSC	SKENT	DEG_APCC_KENBOX_2	0.1389
p.S1358L	ACH-002163	Breast Cancer	CCLE	SKENT	DEG_APCC_KENBOX_2	0.1389
p.S1358L	MRK-nu-1	breast	COSMIC	SKENT	DEG_APCC_KENBOX_2	0.1389
p.I1342T	SIDM00126	Melanoma	GDSC	SKENT	DEG_APCC_KENBOX_2	0.1944
p.I1342T	ACH-002147	Skin Cancer	CCLE	SKENT	DEG_APCC_KENBOX_2	0.1944
p.I1342T	K2	skin	COSMIC	SKENT	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60861	Growth arrest-specific protein 7	DEG_APCC_KENBOX_2	169:173	SKENT	APC,CDC20,FZR1	0.8832	More...
P56715	Oxygen-regulated protein 1	DEG_APCC_KENBOX_2	1347:1351	SKENT	APC,CDC20,FZR1	0.9775	More...
Q5UIP0	Telomere-associated protein RIF1	DEG_APCC_KENBOX_2	1384:1388	SKENT	APC,CDC20,FZR1	0.9973	More...
Q5UIP0	Telomere-associated protein RIF1	DEG_APCC_KENBOX_2	1818:1822	SKENT	APC,CDC20,FZR1	0.9945	More...
Q7Z5K2	Wings apart-like protein homolog	DEG_APCC_KENBOX_2	535:539	SKENT	APC,CDC20,FZR1	0.9938	More...
Q9NXR8	Inhibitor of growth protein 3	DEG_APCC_KENBOX_2	180:184	SKENT	APC,CDC20,FZR1	0.8218	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SKENT

Degron related mutations and impact score

Drug responses associated with RP1 mutations

All proteins holding degron of SKENT