DegronMD

Uniprot ID: Q5UIP0

Source protein: Telomere-associated protein RIF1

Source gene: RIF1

Class: DEG_SPOP_SBC_1

Location: 1425:1429

E3 ligase: SPOP

DEGRON score: 0.9633

ASA_SCORE: 100.94

COIL: 0.911

CONS_SCORE: 0.2968

DSS_SCORE: 0.691

HELIX: 0.0486

FCONS_SCORE: 0.8712

RIG_SCORE: 0.6112

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1416L	TCGA-17-Z043	LUAD	TCGA	VESTT	DEG_SPOP_SBC_1	0.0833
p.S1431N	TCGA-73-4668	LUAD	TCGA	VESTT	DEG_SPOP_SBC_1	0.7222
p.S1431N	DO23961	LUAD	ICGC	VESTT	DEG_SPOP_SBC_1	0.7222
p.R1421C	TCGA-AX-A1CE	UCEC	TCGA	VESTT	DEG_SPOP_SBC_1	0.2222
p.R1421C	TCGA-FI-A2D5	UCEC	TCGA	VESTT	DEG_SPOP_SBC_1	0.2222
p.R1421C	DO42280	UCEC	ICGC	VESTT	DEG_SPOP_SBC_1	0.2222
p.R1421C	DO41331	UCEC	ICGC	VESTT	DEG_SPOP_SBC_1	0.2222
p.R1420Q	TCGA-VS-A94X	CESC	TCGA	VESTT	DEG_SPOP_SBC_1	0.1944
p.R1420Q	DO51632	CESC	ICGC	VESTT	DEG_SPOP_SBC_1	0.1944
p.S1427P	SIDM02059	Colorectal Carcinoma	GDSC	VESTT	DEG_SPOP_SBC_1	0.7863
p.E1430G	SIDM01090	Colorectal Carcinoma	GDSC	VESTT	DEG_SPOP_SBC_1	0.3056
p.E1430G	ACH-000943	Colon/Colorectal Cancer	CCLE	VESTT	DEG_SPOP_SBC_1	0.3056
p.E1430G	RKO	large_intestine	COSMIC	VESTT	DEG_SPOP_SBC_1	0.3056
p.T1428I	SIDM01199	Hepatocellular Carcinoma	GDSC	VESTT	DEG_SPOP_SBC_1	0.8189
p.T1428I	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	VESTT	DEG_SPOP_SBC_1	0.8189
p.T1428I	SIDM01559	Melanoma	GDSC	VESTT	DEG_SPOP_SBC_1	0.8189
p.R1419W	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	VESTT	DEG_SPOP_SBC_1	0.1667
p.R1419W	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	VESTT	DEG_SPOP_SBC_1	0.1667
p.R1416Q	SIDM00500	Colorectal Carcinoma	GDSC	VESTT	DEG_SPOP_SBC_1	0.0833
p.R1416Q	ACH-000959	Colon/Colorectal Cancer	CCLE	VESTT	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5UIP0	Telomere-associated protein RIF1	DEG_SPOP_SBC_1	1425:1429	VESTT	SPOP	0.9633	More...
Q9UMS6	Synaptopodin-2	DEG_SPOP_SBC_1	113:117	VESTT	SPOP	0.9987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons