DegronMD

Uniprot ID: Q5UIP0

Source protein: Telomere-associated protein RIF1

Source gene: RIF1

Class: DEG_SCF_FBW7_2

Location: 1884:1891

E3 ligase: FBXW7

DEGRON score: 0.997

ASA_SCORE: 114.9125

COIL: 0.8636

CONS_SCORE: 0.2188

DSS_SCORE: 0.6493

HELIX: 0.1089

FCONS_SCORE: 1.1403

RIG_SCORE: 0.7014

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1891V	TCGA-B5-A1MX	UCEC	TCGA	PEETPKME	DEG_SCF_FBW7_2	0.7693
p.E1891V	DO41999	UCEC	ICGC	PEETPKME	DEG_SCF_FBW7_2	0.7693
p.E1900D	DO50827	LIRI	ICGC	PEETPKME	DEG_SCF_FBW7_2	0.0833
p.L1892P	SIDM02026	Colorectal Carcinoma	GDSC	PEETPKME	DEG_SCF_FBW7_2	0.3056
p.Q1874H	SIDM00373	Endometrial Carcinoma	GDSC	PEETPKME	DEG_SCF_FBW7_2	0.0556
p.Q1874H	ACH-000974	Endometrial/Uterine Cancer	CCLE	PEETPKME	DEG_SCF_FBW7_2	0.0556
p.E1878K	SIDM00789	Colorectal Carcinoma	GDSC	PEETPKME	DEG_SCF_FBW7_2	0.1667
p.E1878K	ACH-000997	Colon/Colorectal Cancer	CCLE	PEETPKME	DEG_SCF_FBW7_2	0.1667
p.E1878K	ACH-001061	Colon/Colorectal Cancer	CCLE	PEETPKME	DEG_SCF_FBW7_2	0.1667
p.E1878K	ACH-001091	Colon/Colorectal Cancer	CCLE	PEETPKME	DEG_SCF_FBW7_2	0.1667
p.E1878K	HCT-15	large_intestine	COSMIC	PEETPKME	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5UIP0	Telomere-associated protein RIF1	DEG_SCF_FBW7_2	1884:1891	PEETPKME	FBXW7	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons