DegronMD

Uniprot ID: Q9UMS6

Source protein: Synaptopodin-2

Source gene: SYNPO2

Class: DEG_SPOP_SBC_1

Location: 765:769

E3 ligase: SPOP

DEGRON score: 0.9977

ASA_SCORE: 95.72

COIL: 0.9472

CONS_SCORE: 0.5321

DSS_SCORE: 0.5766

HELIX: 0.034

FCONS_SCORE: 0.843

RIG_SCORE: 0.5715

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V759L	TCGA-50-5930	LUAD	TCGA	VKSSS	DEG_SPOP_SBC_1	0.1667
p.V759L	DO25189	LUAD	ICGC	VKSSS	DEG_SPOP_SBC_1	0.1667
p.T755I	TCGA-AA-A00N	COAD	TCGA	VKSSS	DEG_SPOP_SBC_1	0.5
p.T755I	DO9876	COAD	ICGC	VKSSS	DEG_SPOP_SBC_1	0.5
p.P757H	TCGA-AJ-A3EL	UCEC	TCGA	VKSSS	DEG_SPOP_SBC_1	0.1111
p.P757H	DO41542	UCEC	ICGC	VKSSS	DEG_SPOP_SBC_1	0.1111
p.A760T	DO231549	LINC	ICGC	VKSSS	DEG_SPOP_SBC_1	0.1944
p.A764V	DO220865	MELA	ICGC	VKSSS	DEG_SPOP_SBC_1	0.3056
p.T770S	NCI-H128	lung	COSMIC	VKSSS	DEG_SPOP_SBC_1	0.75
p.P755S	Mewo	skin	COSMIC	VKSSS	DEG_SPOP_SBC_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60882	Matrix metalloproteinase-20	DEG_SPOP_SBC_1	475:479	VKSSS	SPOP	0.6246	More...
O75952	Calcium-binding tyrosine phosphorylation-regulated protein	DEG_SPOP_SBC_1	465:469	VKSSS	SPOP	0.975	More...
P29375	Lysine-specific demethylase 5A	DEG_SPOP_SBC_1	1363:1367	VKSSS	SPOP	0.9347	More...
P55197	Protein AF-10	DEG_SPOP_SBC_1	360:364	VKSSS	SPOP	0.8251	More...
Q2LD37	Transmembrane protein KIAA1109	DEG_SPOP_SBC_1	2319:2323	VKSSS	SPOP	0.9728	More...
Q5CZC0	Fibrous sheath-interacting protein 2	DEG_SPOP_SBC_1	3936:3940	VKSSS	SPOP	0.9325	More...
Q5U651	Ras-interacting protein 1	DEG_SPOP_SBC_1	45:49	VKSSS	SPOP	0.9869	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	686:690	VKSSS	SPOP	0.9003	More...
Q8IVL0	Neuron navigator 3	DEG_SPOP_SBC_1	1269:1273	VKSSS	SPOP	0.9831	More...
Q9UMS6	Synaptopodin-2	DEG_SPOP_SBC_1	765:769	VKSSS	SPOP	0.9977	More...
Q2KJY2	Kinesin-like protein KIF26B	DEG_SPOP_SBC_1	1532:1536	VKSSS	SPOP	0.9092	More...
Q5JRM2	Uncharacterized protein CXorf66	DEG_SPOP_SBC_1	303:307	VKSSS	SPOP	0.9382	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons