DegronMD - O75952(CABYR)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I261V	TCGA-24-1417	OV	TCGA	PPAY	ITCH	270:273	Mutation rewiring degron network	0.0833
p.I261V	DO32019	OV	ICGC	PPAY	ITCH	270:273	Mutation rewiring degron network	0.0833
p.N266S	TCGA-43-5668	LUSC	TCGA	PPAY	ITCH	270:273	Mutation rewiring degron network	0.2222
p.N266S	DO26608	LUSC	ICGC	PPAY	ITCH	270:273	Mutation rewiring degron network	0.2222
p.E135K	TCGA-44-7667	LUAD	TCGA	PATPKTT	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0833
p.E135K	DO23830	LUAD	ICGC	PATPKTT	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0833
p.V263I	TCGA-AO-A03R	BRCA	TCGA	PPAY	ITCH	270:273	Mutation rewiring degron network	0.1389
p.V263I	DO3530	BRCA	ICGC	PPAY	ITCH	270:273	Mutation rewiring degron network	0.1389
p.V282I	TCGA-B5-A3FA	UCEC	TCGA	PPAY	ITCH	270:273	Mutation rewiring degron network	0.0833
p.V282I	DO52402	UCEC	ICGC	PPAY	ITCH	270:273	Mutation rewiring degron network	0.0833
p.P277A	TCGA-CV-A463	HNSC	TCGA	PPAY	ITCH	270:273	Mutation rewiring degron network	0.2222
p.P277A	DO52066	HNSC	ICGC	PPAY	ITCH	270:273	Mutation rewiring degron network	0.2222
p.P156L	TCGA-EE-A2GU	SKCM	TCGA	PATPKTT	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1667
p.P156L	DO37639	SKCM	ICGC	PATPKTT	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1667
p.T134M	TCGA-EW-A1IZ	BRCA	TCGA	PATPKTT	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0556
p.T134M	DO2937	BRCA	ICGC	PATPKTT	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0556
p.T134M	DO222454	BTCA	ICGC	PATPKTT	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0556
p.P152T	TCGA-VS-A9V1	CESC	TCGA	PATPKTT	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.2778
p.P152T	DO51648	CESC	ICGC	PATPKTT	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.2778
p.S265L	TCGA-XF-A9SJ	BLCA	TCGA	PPAY	ITCH	270:273	Mutation rewiring degron network	0.1944
p.S265L	DO219045	BLCA	ICGC	PPAY	ITCH	270:273	Mutation rewiring degron network	0.1944
p.Y276H	DO222404	BTCA	ICGC	PPAY	ITCH	270:273	Mutation rewiring degron network	0.25
p.A274T	DO51729	COAD	ICGC	PPAY	ITCH	270:273	Mutation rewiring degron network	0.3056
p.A280T	DO220875	MELA	ICGC	PPAY	ITCH	270:273	Mutation rewiring degron network	0.1389
p.S277P	DO46581	OV	ICGC	PPAY	ITCH	270:273	Mutation rewiring degron network	0.2222
p.E157K	DO37432	SKCM	ICGC	PATPKTT	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1389
p.V137A	DO51742	STAD	ICGC	PATPKTT	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1389
p.E267D	SIDM01062	Breast Carcinoma	GDSC	PPAY	ITCH	270:273	Mutation rewiring degron network	0.25
p.E267D	SIDM00966	Ovarian Carcinoma	GDSC	PPAY	ITCH	270:273	Mutation rewiring degron network	0.25
p.E267D	OVCA433	ovary	COSMIC	PPAY	ITCH	270:273	Mutation rewiring degron network	0.25
p.E267D	HDQ-P1	breast	COSMIC	PPAY	ITCH	270:273	Mutation rewiring degron network	0.25
p.A145T	SIDM00660	Colorectal Carcinoma	GDSC	PATPKTT	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.6028
p.A145T	ACH-000985	Colon/Colorectal Cancer	CCLE	PATPKTT	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.6028
p.A145T	LS-411N	large intestine	COSMIC	PATPKTT	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.6028
p.E272D	ACH-000991	Colon/Colorectal Cancer	CCLE	PPAY	ITCH	270:273	Mutation altering degron motif	0.6758
p.E272D	SNU-81	large intestine	COSMIC	PPAY	ITCH	270:273	Mutation altering degron motif	0.6758
p.G152D	CCK-81	large intestine	COSMIC	PATPKTT	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.2778

Kaplan plot for CABYR in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CABYR

UniProt ID: O75952

Entrez ID: 26256

Protein name: Calcium-binding tyrosine phosphorylation-regulated protein (Calcium-binding protein 86) (Cancer/testis antigen 88) (CT88) (Fibrousheathin II) (Fibrousheathin-2) (FSP-2) (Testis-specific calcium-binding protein CBP86)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CABYR in