DegronMD

Uniprot ID: O75952

Source protein: Calcium-binding tyrosine phosphorylation-regulated protein

Source gene: CABYR

Class: DEG_SCF_FBW7_1

Location: 144:150

E3 ligase: FBXW7

DEGRON score: 0.7359

ASA_SCORE: 102.1143

COIL: 0.9476

CONS_SCORE: 0.5344

DSS_SCORE: 0.7189

HELIX: 0.0163

FCONS_SCORE: 0.9527

RIG_SCORE: 0.584

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E135K	TCGA-44-7667	LUAD	TCGA	PATPKTT	DEG_SCF_FBW7_1	0.0833
p.E135K	DO23830	LUAD	ICGC	PATPKTT	DEG_SCF_FBW7_1	0.0833
p.P156L	TCGA-EE-A2GU	SKCM	TCGA	PATPKTT	DEG_SCF_FBW7_1	0.1667
p.P156L	DO37639	SKCM	ICGC	PATPKTT	DEG_SCF_FBW7_1	0.1667
p.T134M	TCGA-EW-A1IZ	BRCA	TCGA	PATPKTT	DEG_SCF_FBW7_1	0.0556
p.T134M	DO2937	BRCA	ICGC	PATPKTT	DEG_SCF_FBW7_1	0.0556
p.T134M	DO222454	BTCA	ICGC	PATPKTT	DEG_SCF_FBW7_1	0.0556
p.P152T	TCGA-VS-A9V1	CESC	TCGA	PATPKTT	DEG_SCF_FBW7_1	0.2778
p.P152T	DO51648	CESC	ICGC	PATPKTT	DEG_SCF_FBW7_1	0.2778
p.E157K	DO37432	SKCM	ICGC	PATPKTT	DEG_SCF_FBW7_1	0.1389
p.V137A	DO51742	STAD	ICGC	PATPKTT	DEG_SCF_FBW7_1	0.1389
p.A145T	SIDM00660	Colorectal Carcinoma	GDSC	PATPKTT	DEG_SCF_FBW7_1	0.6028
p.A145T	ACH-000985	Colon/Colorectal Cancer	CCLE	PATPKTT	DEG_SCF_FBW7_1	0.6028
p.A145T	LS-411N	large_intestine	COSMIC	PATPKTT	DEG_SCF_FBW7_1	0.6028
p.G152D	CCK-81	large_intestine	COSMIC	PATPKTT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75952	Calcium-binding tyrosine phosphorylation-regulated protein	DEG_SCF_FBW7_1	144:150	PATPKTT	FBXW7	0.7359	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons