DegronMD

Uniprot ID: Q8IVL0

Source protein: Neuron navigator 3

Source gene: NAV3

Class: DEG_SPOP_SBC_1

Location: 1269:1273

E3 ligase: SPOP

DEGRON score: 0.9831

ASA_SCORE: 79.46

COIL: 0.9062

CONS_SCORE: 0.3403

DSS_SCORE: 0.6342

HELIX: 0.0362

FCONS_SCORE: 0.944

RIG_SCORE: 0.6332

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1283E	TCGA-56-8628	LUSC	TCGA	VKSSS	DEG_SPOP_SBC_1	0.0556
p.A1283E	DO45433	LUSC	ICGC	VKSSS	DEG_SPOP_SBC_1	0.0556
p.T1266N	TCGA-66-2763	LUSC	TCGA	VKSSS	DEG_SPOP_SBC_1	0.25
p.T1266N	DO27620	LUSC	ICGC	VKSSS	DEG_SPOP_SBC_1	0.25
p.S1273L	TCGA-75-6214	LUAD	TCGA	VKSSS	DEG_SPOP_SBC_1	0.7667
p.S1273L	TCGA-UY-A78P	BLCA	TCGA	VKSSS	DEG_SPOP_SBC_1	0.7667
p.S1273L	DO219036	BLCA	ICGC	VKSSS	DEG_SPOP_SBC_1	0.7667
p.S1273L	DO24830	LUAD	ICGC	VKSSS	DEG_SPOP_SBC_1	0.7667
p.V1269M	TCGA-A5-A0R8	UCEC	TCGA	VKSSS	DEG_SPOP_SBC_1	0.7208
p.V1269M	DO42584	UCEC	ICGC	VKSSS	DEG_SPOP_SBC_1	0.7208
p.K1270E	TCGA-AP-A056	UCEC	TCGA	VKSSS	DEG_SPOP_SBC_1	0.591
p.K1270E	DO43971	UCEC	ICGC	VKSSS	DEG_SPOP_SBC_1	0.591
p.L1282S	TCGA-DD-AADC	LIHC	TCGA	VKSSS	DEG_SPOP_SBC_1	0.0833
p.L1282S	DO52230	LIHC	ICGC	VKSSS	DEG_SPOP_SBC_1	0.0833
p.P1278H	TCGA-EE-A2M8	SKCM	TCGA	VKSSS	DEG_SPOP_SBC_1	0.1944
p.P1278H	DO38075	SKCM	ICGC	VKSSS	DEG_SPOP_SBC_1	0.1944
p.S1262C	TCGA-G2-A3IE	BLCA	TCGA	VKSSS	DEG_SPOP_SBC_1	0.1389
p.S1262C	DO767	BLCA	ICGC	VKSSS	DEG_SPOP_SBC_1	0.1389
p.S1262C	DO48222	ESCA	ICGC	VKSSS	DEG_SPOP_SBC_1	0.1389
p.S1260C	TCGA-HG-A2PA	CESC	TCGA	VKSSS	DEG_SPOP_SBC_1	0.0833
p.S1260C	DO6311	CESC	ICGC	VKSSS	DEG_SPOP_SBC_1	0.0833
p.S1262F	TCGA-UY-A78O	BLCA	TCGA	VKSSS	DEG_SPOP_SBC_1	0.1389
p.S1262F	DO219035	BLCA	ICGC	VKSSS	DEG_SPOP_SBC_1	0.1389
p.L1282F	DO232019	LICA	ICGC	VKSSS	DEG_SPOP_SBC_1	0.0833
p.S1279N	DO231086	LUSC	ICGC	VKSSS	DEG_SPOP_SBC_1	0.1667
p.S1272Y	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	VKSSS	DEG_SPOP_SBC_1	0.712
p.S1272Y	ACH-000789	Lung Cancer	CCLE	VKSSS	DEG_SPOP_SBC_1	0.712
p.S1272Y	NCI-H810	lung	COSMIC	VKSSS	DEG_SPOP_SBC_1	0.712
p.V1274A	SIDM00537	Colorectal Carcinoma	GDSC	VKSSS	DEG_SPOP_SBC_1	0.3056
p.V1274A	ACH-001345	Colon/Colorectal Cancer	CCLE	VKSSS	DEG_SPOP_SBC_1	0.3056
p.V1274A	GP5d	large_intestine	COSMIC	VKSSS	DEG_SPOP_SBC_1	0.3056
p.P1264H	ACH-000568	Breast Cancer	CCLE	VKSSS	DEG_SPOP_SBC_1	0.1944
p.T1280I	ACH-000776	Brain Cancer	CCLE	VKSSS	DEG_SPOP_SBC_1	0.1389
p.T1272M	TYK-nu	ovary	COSMIC	VKSSS	DEG_SPOP_SBC_1	0.7423
p.S1280N	BV-173	haematopoietic_and_lymphoid_tissue	COSMIC	VKSSS	DEG_SPOP_SBC_1	0.1389
p.D1273Y	NCI-H128	lung	COSMIC	VKSSS	DEG_SPOP_SBC_1	0.7325
p.L1269I	CW-2	large_intestine	COSMIC	VKSSS	DEG_SPOP_SBC_1	0.7174

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60882	Matrix metalloproteinase-20	DEG_SPOP_SBC_1	475:479	VKSSS	SPOP	0.6246	More...
O75952	Calcium-binding tyrosine phosphorylation-regulated protein	DEG_SPOP_SBC_1	465:469	VKSSS	SPOP	0.975	More...
P29375	Lysine-specific demethylase 5A	DEG_SPOP_SBC_1	1363:1367	VKSSS	SPOP	0.9347	More...
P55197	Protein AF-10	DEG_SPOP_SBC_1	360:364	VKSSS	SPOP	0.8251	More...
Q2LD37	Transmembrane protein KIAA1109	DEG_SPOP_SBC_1	2319:2323	VKSSS	SPOP	0.9728	More...
Q5CZC0	Fibrous sheath-interacting protein 2	DEG_SPOP_SBC_1	3936:3940	VKSSS	SPOP	0.9325	More...
Q5U651	Ras-interacting protein 1	DEG_SPOP_SBC_1	45:49	VKSSS	SPOP	0.9869	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	686:690	VKSSS	SPOP	0.9003	More...
Q8IVL0	Neuron navigator 3	DEG_SPOP_SBC_1	1269:1273	VKSSS	SPOP	0.9831	More...
Q9UMS6	Synaptopodin-2	DEG_SPOP_SBC_1	765:769	VKSSS	SPOP	0.9977	More...
Q2KJY2	Kinesin-like protein KIF26B	DEG_SPOP_SBC_1	1532:1536	VKSSS	SPOP	0.9092	More...
Q5JRM2	Uncharacterized protein CXorf66	DEG_SPOP_SBC_1	303:307	VKSSS	SPOP	0.9382	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VKSSS

Degron related mutations and impact score

Drug responses associated with NAV3 mutations

All proteins holding degron of VKSSS