DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
VKSSS
Uniprot ID:
O75952
Source protein:
Calcium-binding tyrosine phosphorylation-regulated protein
Source gene:
CABYR
Class:
DEG_SPOP_SBC_1
Location:
465:469
E3 ligase:
SPOP
DEGRON score:
0.975
ASA_SCORE:
81.74
COIL:
0.8338
CONS_SCORE:
0.4192
DSS_SCORE:
0.6729
HELIX:
0.0328
FCONS_SCORE:
0.9632
RIG_SCORE:
0.5408
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CABYR mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VKSSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O60882
Matrix metalloproteinase-20
DEG_SPOP_SBC_1
475:479
VKSSS
SPOP
0.6246
More...
O75952
Calcium-binding tyrosine phosphorylation-regulated protein
DEG_SPOP_SBC_1
465:469
VKSSS
SPOP
0.975
More...
P29375
Lysine-specific demethylase 5A
DEG_SPOP_SBC_1
1363:1367
VKSSS
SPOP
0.9347
More...
P55197
Protein AF-10
DEG_SPOP_SBC_1
360:364
VKSSS
SPOP
0.8251
More...
Q2LD37
Transmembrane protein KIAA1109
DEG_SPOP_SBC_1
2319:2323
VKSSS
SPOP
0.9728
More...
Q5CZC0
Fibrous sheath-interacting protein 2
DEG_SPOP_SBC_1
3936:3940
VKSSS
SPOP
0.9325
More...
Q5U651
Ras-interacting protein 1
DEG_SPOP_SBC_1
45:49
VKSSS
SPOP
0.9869
More...
Q6P4R8
Nuclear factor related to kappa-B-binding protein
DEG_SPOP_SBC_1
686:690
VKSSS
SPOP
0.9003
More...
Q8IVL0
Neuron navigator 3
DEG_SPOP_SBC_1
1269:1273
VKSSS
SPOP
0.9831
More...
Q9UMS6
Synaptopodin-2
DEG_SPOP_SBC_1
765:769
VKSSS
SPOP
0.9977
More...
Q2KJY2
Kinesin-like protein KIF26B
DEG_SPOP_SBC_1
1532:1536
VKSSS
SPOP
0.9092
More...
Q5JRM2
Uncharacterized protein CXorf66
DEG_SPOP_SBC_1
303:307
VKSSS
SPOP
0.9382
More...