DegronMD - Q5U651(RASIP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R38C	TCGA-AX-A2HC	UCEC	TCGA	PRKQLAKLG	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.2778
p.R38C	TCGA-AX-A2HC	UCEC	TCGA	VKSSS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.1389
p.R38C	DO41572	UCEC	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.2778
p.R38C	DO41572	UCEC	ICGC	VKSSS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.1389
p.A42T	TCGA-AX-A2HD	UCEC	TCGA	PRKQLAKLG	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.1667
p.A42T	TCGA-AX-A2HD	UCEC	TCGA	VKSSS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.25
p.A42T	DO42608	UCEC	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.1667
p.A42T	DO42608	UCEC	ICGC	VKSSS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.25
p.P20S	TCGA-D3-A2JD	SKCM	TCGA	PRKQLAKLG	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.1111
p.P20S	DO37543	SKCM	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.1111
p.P20H	TCGA-DA-A1I1	SKCM	TCGA	PRKQLAKLG	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.1111
p.P20H	DO37966	SKCM	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.1111
p.P28L	TCGA-EE-A181	SKCM	TCGA	PRKQLAKLG	DEG_APCC_DBOX_1	28:36	Mutation altering degron motif	0.6471
p.P28L	DO37444	SKCM	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	28:36	Mutation altering degron motif	0.6471
p.G36W	TCGA-EE-A184	SKCM	TCGA	PRKQLAKLG	DEG_APCC_DBOX_1	28:36	Mutation altering degron motif	0.6714
p.G36W	DO47442	SKCM	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	28:36	Mutation altering degron motif	0.6714
p.P28T	TCGA-EE-A3AD	SKCM	TCGA	PRKQLAKLG	DEG_APCC_DBOX_1	28:36	Mutation altering degron motif	0.5919
p.P28T	DO37707	SKCM	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	28:36	Mutation altering degron motif	0.5919
p.G22D	TCGA-FI-A2D5	UCEC	TCGA	PRKQLAKLG	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.1667
p.G22D	DO41331	UCEC	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.1667
p.N26H	DO222984	BTCA	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.2778
p.N26H	DO229373	BTCA	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.2778
p.V21M	DO233864	GACA	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.1389
p.R37W	DO41199	UCEC	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.3056
p.R37W	DO41199	UCEC	ICGC	VKSSS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.1111
p.A33V	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PRKQLAKLG	DEG_APCC_DBOX_1	28:36	Mutation altering degron motif	0.5825
p.A33V	ACH-000983	Leukemia	CCLE	PRKQLAKLG	DEG_APCC_DBOX_1	28:36	Mutation altering degron motif	0.5825
p.A33V	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PRKQLAKLG	DEG_APCC_DBOX_1	28:36	Mutation altering degron motif	0.5825
p.W39L	SIDM00457	Plasma Cell Myeloma	GDSC	PRKQLAKLG	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.25
p.W39L	SIDM00457	Plasma Cell Myeloma	GDSC	VKSSS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.1667
p.W39L	ACH-000024	Myeloma	CCLE	PRKQLAKLG	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.25
p.W39L	ACH-000024	Myeloma	CCLE	VKSSS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.1667
p.W39L	OPM-2	haematopoietic and lymphoid tissue	COSMIC	PRKQLAKLG	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.25
p.W39L	OPM-2	haematopoietic and lymphoid tissue	COSMIC	VKSSS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.1667
p.P40H	SIDM00143	Small Cell Lung Carcinoma	GDSC	PRKQLAKLG	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.2222
p.P40H	SIDM00143	Small Cell Lung Carcinoma	GDSC	VKSSS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.1944
p.P40H	ACH-000803	Lung Cancer	CCLE	PRKQLAKLG	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.2222
p.P40H	ACH-000803	Lung Cancer	CCLE	VKSSS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.1944
p.P40H	COLO-668	lung	COSMIC	PRKQLAKLG	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.2222
p.P40H	COLO-668	lung	COSMIC	VKSSS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.1944

Kaplan plot for RASIP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RASIP1

UniProt ID: Q5U651

Entrez ID: 54922

Protein name: Ras-interacting protein 1 (Rain)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RASIP1 in