DegronMD

Uniprot ID: Q5U651

Source protein: Ras-interacting protein 1

Source gene: RASIP1

Class: DEG_APCC_DBOX_1

Location: 28:36

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9347

ASA_SCORE: 71.5667

COIL: 0.2677

CONS_SCORE: 0.7283

DSS_SCORE: 0.4202

HELIX: 0.718

FCONS_SCORE: 0.9819

RIG_SCORE: 0.7805

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G36W	TCGA-EE-A184	SKCM	TCGA	PRKQLAKLG	DEG_APCC_DBOX_1	0.6714
p.G36W	DO47442	SKCM	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	0.6714
p.P28L	TCGA-EE-A181	SKCM	TCGA	PRKQLAKLG	DEG_APCC_DBOX_1	0.6471
p.P28L	DO37444	SKCM	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	0.6471
p.P28T	TCGA-EE-A3AD	SKCM	TCGA	PRKQLAKLG	DEG_APCC_DBOX_1	0.5919
p.P28T	DO37707	SKCM	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	0.5919
p.A33V	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PRKQLAKLG	DEG_APCC_DBOX_1	0.5825
p.A33V	ACH-000983	Leukemia	CCLE	PRKQLAKLG	DEG_APCC_DBOX_1	0.5825
p.A33V	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PRKQLAKLG	DEG_APCC_DBOX_1	0.5825
p.R37W	DO41199	UCEC	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	0.3056
p.R38C	TCGA-AX-A2HC	UCEC	TCGA	PRKQLAKLG	DEG_APCC_DBOX_1	0.2778
p.R38C	DO41572	UCEC	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	0.2778
p.N26H	DO222984	BTCA	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	0.2778
p.N26H	DO229373	BTCA	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	0.2778
p.W39L	SIDM00457	Plasma Cell Myeloma	GDSC	PRKQLAKLG	DEG_APCC_DBOX_1	0.25
p.W39L	ACH-000024	Myeloma	CCLE	PRKQLAKLG	DEG_APCC_DBOX_1	0.25
p.W39L	OPM-2	haematopoietic_and_lymphoid_tissue	COSMIC	PRKQLAKLG	DEG_APCC_DBOX_1	0.25
p.P40H	SIDM00143	Small Cell Lung Carcinoma	GDSC	PRKQLAKLG	DEG_APCC_DBOX_1	0.2222
p.P40H	ACH-000803	Lung Cancer	CCLE	PRKQLAKLG	DEG_APCC_DBOX_1	0.2222
p.P40H	COLO-668	lung	COSMIC	PRKQLAKLG	DEG_APCC_DBOX_1	0.2222
p.A42T	TCGA-AX-A2HD	UCEC	TCGA	PRKQLAKLG	DEG_APCC_DBOX_1	0.1667
p.A42T	DO42608	UCEC	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	0.1667
p.G22D	TCGA-FI-A2D5	UCEC	TCGA	PRKQLAKLG	DEG_APCC_DBOX_1	0.1667
p.G22D	DO41331	UCEC	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	0.1667
p.V21M	DO233864	GACA	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	0.1389

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Drug responses associated with RASIP1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PRKQLAKLG

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5U651	Ras-interacting protein 1	DEG_APCC_DBOX_1	28:36	PRKQLAKLG	APC,CDC20,FZR1	0.9347	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRKQLAKLG

Degron related mutations and impact score

Drug responses associated with RASIP1 mutations

All proteins holding degron of PRKQLAKLG