DegronMD

Uniprot ID: Q5U651

Source protein: Ras-interacting protein 1

Source gene: RASIP1

Class: DEG_APCC_DBOX_1

Location: 28:36

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9347

ASA_SCORE: 71.5667

COIL: 0.2677

CONS_SCORE: 0.7283

DSS_SCORE: 0.4202

HELIX: 0.718

FCONS_SCORE: 0.9819

RIG_SCORE: 0.7805

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R38C	TCGA-AX-A2HC	UCEC	TCGA	PRKQLAKLG	DEG_APCC_DBOX_1	0.2778
p.R38C	DO41572	UCEC	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	0.2778
p.A42T	TCGA-AX-A2HD	UCEC	TCGA	PRKQLAKLG	DEG_APCC_DBOX_1	0.1667
p.A42T	DO42608	UCEC	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	0.1667
p.P20S	TCGA-D3-A2JD	SKCM	TCGA	PRKQLAKLG	DEG_APCC_DBOX_1	0.1111
p.P20S	DO37543	SKCM	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	0.1111
p.P20H	TCGA-DA-A1I1	SKCM	TCGA	PRKQLAKLG	DEG_APCC_DBOX_1	0.1111
p.P20H	DO37966	SKCM	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	0.1111
p.P28L	TCGA-EE-A181	SKCM	TCGA	PRKQLAKLG	DEG_APCC_DBOX_1	0.6471
p.P28L	DO37444	SKCM	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	0.6471
p.G36W	TCGA-EE-A184	SKCM	TCGA	PRKQLAKLG	DEG_APCC_DBOX_1	0.6714
p.G36W	DO47442	SKCM	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	0.6714
p.P28T	TCGA-EE-A3AD	SKCM	TCGA	PRKQLAKLG	DEG_APCC_DBOX_1	0.5919
p.P28T	DO37707	SKCM	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	0.5919
p.G22D	TCGA-FI-A2D5	UCEC	TCGA	PRKQLAKLG	DEG_APCC_DBOX_1	0.1667
p.G22D	DO41331	UCEC	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	0.1667
p.N26H	DO222984	BTCA	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	0.2778
p.N26H	DO229373	BTCA	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	0.2778
p.V21M	DO233864	GACA	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	0.1389
p.R37W	DO41199	UCEC	ICGC	PRKQLAKLG	DEG_APCC_DBOX_1	0.3056
p.A33V	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PRKQLAKLG	DEG_APCC_DBOX_1	0.5825
p.A33V	ACH-000983	Leukemia	CCLE	PRKQLAKLG	DEG_APCC_DBOX_1	0.5825
p.A33V	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PRKQLAKLG	DEG_APCC_DBOX_1	0.5825
p.W39L	SIDM00457	Plasma Cell Myeloma	GDSC	PRKQLAKLG	DEG_APCC_DBOX_1	0.25
p.W39L	ACH-000024	Myeloma	CCLE	PRKQLAKLG	DEG_APCC_DBOX_1	0.25
p.W39L	OPM-2	haematopoietic_and_lymphoid_tissue	COSMIC	PRKQLAKLG	DEG_APCC_DBOX_1	0.25
p.P40H	SIDM00143	Small Cell Lung Carcinoma	GDSC	PRKQLAKLG	DEG_APCC_DBOX_1	0.2222
p.P40H	ACH-000803	Lung Cancer	CCLE	PRKQLAKLG	DEG_APCC_DBOX_1	0.2222
p.P40H	COLO-668	lung	COSMIC	PRKQLAKLG	DEG_APCC_DBOX_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRKQLAKLG

Degron related mutations and impact score

Drug responses associated with RASIP1 mutations

All proteins holding degron of PRKQLAKLG

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5U651	Ras-interacting protein 1	DEG_APCC_DBOX_1	28:36	PRKQLAKLG	APC,CDC20,FZR1	0.9347	More...