DegronMD

Uniprot ID: Q6P4R8

Source protein: Nuclear factor related to kappa-B-binding protein

Source gene: NFRKB

Class: DEG_SPOP_SBC_1

Location: 686:690

E3 ligase: SPOP

DEGRON score: 0.9003

ASA_SCORE: 96.56

COIL: 0.9138

CONS_SCORE: 0.428

DSS_SCORE: 0.7025

HELIX: 0.0482

FCONS_SCORE: 1.0423

RIG_SCORE: 0.5648

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R677H	TCGA-XK-AAIW	PRAD	TCGA	VKSSS	DEG_SPOP_SBC_1	0.0833
p.P682A	DO229446	SKCA	ICGC	VKSSS	DEG_SPOP_SBC_1	0.2222
p.P680L	DO37579	SKCM	ICGC	VKSSS	DEG_SPOP_SBC_1	0.1667
p.A693T	SIDM00333	Endometrial Carcinoma	GDSC	VKSSS	DEG_SPOP_SBC_1	0.25
p.A693T	MFE-319	endometrium	COSMIC	VKSSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60882	Matrix metalloproteinase-20	DEG_SPOP_SBC_1	475:479	VKSSS	SPOP	0.6246	More...
O75952	Calcium-binding tyrosine phosphorylation-regulated protein	DEG_SPOP_SBC_1	465:469	VKSSS	SPOP	0.975	More...
P29375	Lysine-specific demethylase 5A	DEG_SPOP_SBC_1	1363:1367	VKSSS	SPOP	0.9347	More...
P55197	Protein AF-10	DEG_SPOP_SBC_1	360:364	VKSSS	SPOP	0.8251	More...
Q2LD37	Transmembrane protein KIAA1109	DEG_SPOP_SBC_1	2319:2323	VKSSS	SPOP	0.9728	More...
Q5CZC0	Fibrous sheath-interacting protein 2	DEG_SPOP_SBC_1	3936:3940	VKSSS	SPOP	0.9325	More...
Q5U651	Ras-interacting protein 1	DEG_SPOP_SBC_1	45:49	VKSSS	SPOP	0.9869	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	686:690	VKSSS	SPOP	0.9003	More...
Q8IVL0	Neuron navigator 3	DEG_SPOP_SBC_1	1269:1273	VKSSS	SPOP	0.9831	More...
Q9UMS6	Synaptopodin-2	DEG_SPOP_SBC_1	765:769	VKSSS	SPOP	0.9977	More...
Q2KJY2	Kinesin-like protein KIF26B	DEG_SPOP_SBC_1	1532:1536	VKSSS	SPOP	0.9092	More...
Q5JRM2	Uncharacterized protein CXorf66	DEG_SPOP_SBC_1	303:307	VKSSS	SPOP	0.9382	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons