DegronMD

Uniprot ID: Q5JRM2

Source protein: Uncharacterized protein CXorf66

Source gene: CXorf66

Class: DEG_SPOP_SBC_1

Location: 130:134

E3 ligase: SPOP

DEGRON score: 0.8302

ASA_SCORE: 80.82

COIL: 0.8792

CONS_SCORE: 0.4823

DSS_SCORE: 0.7287

HELIX: 0.1062

FCONS_SCORE: 0.7536

RIG_SCORE: 0.5873

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S132F	TCGA-23-1113	OV	TCGA	AQSST	DEG_SPOP_SBC_1	0.7982
p.S132F	DO32093	OV	ICGC	AQSST	DEG_SPOP_SBC_1	0.7982
p.I138V	TCGA-37-A5EL	LUSC	TCGA	AQSST	DEG_SPOP_SBC_1	0.2222
p.I138V	DO223718	LUSC	ICGC	AQSST	DEG_SPOP_SBC_1	0.2222
p.S122A	TCGA-AG-A002	READ	TCGA	AQSST	DEG_SPOP_SBC_1	0.1111
p.A130T	TCGA-B5-A3FC	UCEC	TCGA	AQSST	DEG_SPOP_SBC_1	0.7139
p.A130T	TCGA-D9-A1X3	SKCM	TCGA	AQSST	DEG_SPOP_SBC_1	0.7139
p.A130T	DO37456	SKCM	ICGC	AQSST	DEG_SPOP_SBC_1	0.7139
p.A130T	DO41871	UCEC	ICGC	AQSST	DEG_SPOP_SBC_1	0.7139
p.L137I	TCGA-D1-A1NU	UCEC	TCGA	AQSST	DEG_SPOP_SBC_1	0.25
p.L137I	DO43811	UCEC	ICGC	AQSST	DEG_SPOP_SBC_1	0.25
p.A128E	DO229024	LICA	ICGC	AQSST	DEG_SPOP_SBC_1	0.2778
p.P140T	DO229026	LICA	ICGC	AQSST	DEG_SPOP_SBC_1	0.1667
p.P125S	SIDM01220	Glioma	GDSC	AQSST	DEG_SPOP_SBC_1	0.1944
p.P125S	ACH-000760	Brain Cancer	CCLE	AQSST	DEG_SPOP_SBC_1	0.1944
p.P125S	ACH-002269	Brain Cancer	CCLE	AQSST	DEG_SPOP_SBC_1	0.1944
p.S123L	ACH-001991	Primary	CCLE	AQSST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14490	Disks large-associated protein 1	DEG_SPOP_SBC_1	559:563	AQSST	SPOP	0.9964	More...
O95886	Disks large-associated protein 3	DEG_SPOP_SBC_1	558:562	AQSST	SPOP	0.9926	More...
Q7Z6J0	E3 ubiquitin-protein ligase SH3RF1	DEG_SPOP_SBC_1	284:288	AQSST	SPOP	0.9813	More...
Q9BZB8	Cytoplasmic polyadenylation element-binding protein 1	DEG_SPOP_SBC_1	120:124	AQSST	SPOP	0.6813	More...
Q9NZN9	Aryl-hydrocarbon-interacting protein-like 1	DEG_SPOP_SBC_1	344:348	AQSST	SPOP	0.929	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	630:634	AQSST	SPOP	0.992	More...
Q5JRM2	Uncharacterized protein CXorf66	DEG_SPOP_SBC_1	130:134	AQSST	SPOP	0.8302	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons