DegronMD - Q9NZN9(AIPL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E341G	TCGA-73-4670	LUAD	TCGA	AQSST	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.25
p.A344T	TCGA-73-4675	LUAD	TCGA	AQSST	DEG_SPOP_SBC_1	344:348	Mutation altering degron motif	0.7139
p.A344T	TCGA-A5-A0G2	UCEC	TCGA	AQSST	DEG_SPOP_SBC_1	344:348	Mutation altering degron motif	0.7139
p.A344T	ACH-001645	Skin Cancer	CCLE	AQSST	DEG_SPOP_SBC_1	344:348	Mutation altering degron motif	0.7139
p.T356I	TCGA-EV-5903	KIRP	TCGA	AQSST	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.1111
p.A340T	DO233288	GACA	ICGC	AQSST	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.2222
p.A340T	DO20890	KIRP	ICGC	AQSST	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.2222
p.A340T	DO38376	STAD	ICGC	AQSST	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.2222
p.A346E	DO228976	LICA	ICGC	AQSST	DEG_SPOP_SBC_1	344:348	Mutation altering degron motif	0.7701
p.P353H	DO218937	LUAD	ICGC	AQSST	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.1944
p.E337K	DO220902	MELA	ICGC	AQSST	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.1389
p.P354L	DO222843	MELA	ICGC	AQSST	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.1667
p.P358L	SIDM00537	Colorectal Carcinoma	GDSC	AQSST	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.0556
p.P358L	ACH-000982	Colon/Colorectal Cancer	CCLE	AQSST	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.0556
p.P358L	ACH-001345	Colon/Colorectal Cancer	CCLE	AQSST	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.0556
p.P358L	GP5d	large intestine	COSMIC	AQSST	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.0556
p.P336L	GP5d	large intestine	COSMIC	AQSST	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.1111
p.P353L	SW684	soft tissue	COSMIC	AQSST	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.1944
p.P346L	GP5d	large intestine	COSMIC	AQSST	DEG_SPOP_SBC_1	344:348	Mutation altering degron motif	0.7582
p.P351L	SW684	soft tissue	COSMIC	AQSST	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.25
p.P334L	GP5d	large intestine	COSMIC	AQSST	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.0556

Kaplan plot for AIPL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AIPL1

UniProt ID: Q9NZN9

Entrez ID: 23746

Protein name: Aryl-hydrocarbon-interacting protein-like 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AIPL1 in