DegronMD

Uniprot ID: Q9NZN9

Source protein: Aryl-hydrocarbon-interacting protein-like 1

Source gene: AIPL1

Class: DEG_SPOP_SBC_1

Location: 344:348

E3 ligase: SPOP

DEGRON score: 0.929

ASA_SCORE: 98.44

COIL: 0.9374

CONS_SCORE: 0.2355

DSS_SCORE: 0.9365

HELIX: 0.0432

FCONS_SCORE: 0.9771

RIG_SCORE: 0.4778

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E341G	TCGA-73-4670	LUAD	TCGA	AQSST	DEG_SPOP_SBC_1	0.25
p.A344T	TCGA-73-4675	LUAD	TCGA	AQSST	DEG_SPOP_SBC_1	0.7139
p.A344T	TCGA-A5-A0G2	UCEC	TCGA	AQSST	DEG_SPOP_SBC_1	0.7139
p.A344T	ACH-001645	Skin Cancer	CCLE	AQSST	DEG_SPOP_SBC_1	0.7139
p.T356I	TCGA-EV-5903	KIRP	TCGA	AQSST	DEG_SPOP_SBC_1	0.1111
p.A340T	DO233288	GACA	ICGC	AQSST	DEG_SPOP_SBC_1	0.2222
p.A340T	DO20890	KIRP	ICGC	AQSST	DEG_SPOP_SBC_1	0.2222
p.A340T	DO38376	STAD	ICGC	AQSST	DEG_SPOP_SBC_1	0.2222
p.A346E	DO228976	LICA	ICGC	AQSST	DEG_SPOP_SBC_1	0.7701
p.P353H	DO218937	LUAD	ICGC	AQSST	DEG_SPOP_SBC_1	0.1944
p.E337K	DO220902	MELA	ICGC	AQSST	DEG_SPOP_SBC_1	0.1389
p.P354L	DO222843	MELA	ICGC	AQSST	DEG_SPOP_SBC_1	0.1667
p.P358L	SIDM00537	Colorectal Carcinoma	GDSC	AQSST	DEG_SPOP_SBC_1	0.0556
p.P358L	ACH-000982	Colon/Colorectal Cancer	CCLE	AQSST	DEG_SPOP_SBC_1	0.0556
p.P358L	ACH-001345	Colon/Colorectal Cancer	CCLE	AQSST	DEG_SPOP_SBC_1	0.0556
p.P358L	GP5d	large_intestine	COSMIC	AQSST	DEG_SPOP_SBC_1	0.0556
p.P336L	GP5d	large_intestine	COSMIC	AQSST	DEG_SPOP_SBC_1	0.1111
p.P353L	SW684	soft_tissue	COSMIC	AQSST	DEG_SPOP_SBC_1	0.1944
p.P346L	GP5d	large_intestine	COSMIC	AQSST	DEG_SPOP_SBC_1	0.7582
p.P351L	SW684	soft_tissue	COSMIC	AQSST	DEG_SPOP_SBC_1	0.25
p.P334L	GP5d	large_intestine	COSMIC	AQSST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14490	Disks large-associated protein 1	DEG_SPOP_SBC_1	559:563	AQSST	SPOP	0.9964	More...
O95886	Disks large-associated protein 3	DEG_SPOP_SBC_1	558:562	AQSST	SPOP	0.9926	More...
Q7Z6J0	E3 ubiquitin-protein ligase SH3RF1	DEG_SPOP_SBC_1	284:288	AQSST	SPOP	0.9813	More...
Q9BZB8	Cytoplasmic polyadenylation element-binding protein 1	DEG_SPOP_SBC_1	120:124	AQSST	SPOP	0.6813	More...
Q9NZN9	Aryl-hydrocarbon-interacting protein-like 1	DEG_SPOP_SBC_1	344:348	AQSST	SPOP	0.929	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	630:634	AQSST	SPOP	0.992	More...
Q5JRM2	Uncharacterized protein CXorf66	DEG_SPOP_SBC_1	130:134	AQSST	SPOP	0.8302	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons