DegronMD - O95886(DLGAP3)

FUNCTION: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.

GO - Biological processes (BP): modification of synaptic structure [GO:0099563]; regulation of postsynaptic neurotransmitter receptor activity [GO:0098962]; signaling [GO:0023052]

GO - Molecular function (MF): amyloid-beta binding [GO:0001540]; molecular adaptor activity [GO:0060090]

GO - Cellular component (CC): cholinergic synapse [GO:0098981]; glutamatergic synapse [GO:0098978]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic specialization [GO:0099572]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S789F	TCGA-EB-A3Y6	SKCM	TCGA	DSGRAS	DEG_SCF_TRCP1_1	784:789	Mutation altering degron motif	0.7982
p.S789F	DO38081	SKCM	ICGC	DSGRAS	DEG_SCF_TRCP1_1	784:789	Mutation altering degron motif	0.7982
p.R51K	TCGA-EE-A2MS	SKCM	TCGA	PRAGLGHIS	DEG_APCC_DBOX_1	50:58	Mutation altering degron motif	0.7237
p.R51K	DO37567	SKCM	ICGC	PRAGLGHIS	DEG_APCC_DBOX_1	50:58	Mutation altering degron motif	0.7237
p.R787H	TCGA-AP-A1DK	UCEC	TCGA	DSGRAS	DEG_SCF_TRCP1_1	784:789	Mutation altering degron motif	0.7133
p.R787H	DO234437	ESAD	ICGC	DSGRAS	DEG_SCF_TRCP1_1	784:789	Mutation altering degron motif	0.7133
p.R787H	DO233156	GACA	ICGC	DSGRAS	DEG_SCF_TRCP1_1	784:789	Mutation altering degron motif	0.7133
p.R787H	DO42033	UCEC	ICGC	DSGRAS	DEG_SCF_TRCP1_1	784:789	Mutation altering degron motif	0.7133
p.D784E	TCGA-22-5471	LUSC	TCGA	DSGRAS	DEG_SCF_TRCP1_1	784:789	Mutation altering degron motif	0.6758
p.D784E	DO27500	LUSC	ICGC	DSGRAS	DEG_SCF_TRCP1_1	784:789	Mutation altering degron motif	0.6758
p.A52D	DO229015	LICA	ICGC	PRAGLGHIS	DEG_APCC_DBOX_1	50:58	Mutation altering degron motif	0.6682
p.P50L	TCGA-55-8091	LUAD	TCGA	PRAGLGHIS	DEG_APCC_DBOX_1	50:58	Mutation altering degron motif	0.6471
p.P50L	DO45334	LUAD	ICGC	PRAGLGHIS	DEG_APCC_DBOX_1	50:58	Mutation altering degron motif	0.6471
p.I57L	SIDM00845	Burkitt's Lymphoma	GDSC	PRAGLGHIS	DEG_APCC_DBOX_1	50:58	Mutation altering degron motif	0.6063
p.P783L	TCGA-56-6546	LUSC	TCGA	DSGRAS	DEG_SCF_TRCP1_1	784:789	Mutation rewiring degron network	0.3056
p.P783L	DO26542	LUSC	ICGC	DSGRAS	DEG_SCF_TRCP1_1	784:789	Mutation rewiring degron network	0.3056
p.P59S	TCGA-FW-A3R5	SKCM	TCGA	PRAGLGHIS	DEG_APCC_DBOX_1	50:58	Mutation rewiring degron network	0.3056
p.P59S	DO37406	SKCM	ICGC	PRAGLGHIS	DEG_APCC_DBOX_1	50:58	Mutation rewiring degron network	0.3056
p.P792L	TCGA-EE-A2MC	SKCM	TCGA	DSGRAS	DEG_SCF_TRCP1_1	784:789	Mutation rewiring degron network	0.25
p.P792L	TCGA-IH-A3EA	SKCM	TCGA	DSGRAS	DEG_SCF_TRCP1_1	784:789	Mutation rewiring degron network	0.25

Showing 1 to 20 of 52 entries

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Kaplan plot for DLGAP3 in

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

DLGAP3

UniProt ID: O95886

Entrez ID: 58512

Protein name: Disks large-associated protein 3 (DAP-3) (PSD-95/SAP90-binding protein 3) (SAP90/PSD-95-associated protein 3) (SAPAP3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DLGAP3 in